Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in
vitro cell culture that has a promising future in the healthcare industry. The numerous …

Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

Arthritis affects millions of people worldwide. With only a few disease-modifying drugs
available for treatment of rheumatoid arthritis and none for osteoarthritis, a clear need exists …

Despite substantial efforts dedicated to the development of new, nonaddictive analgesics,
success in treating pain has been limited. Clinically available analgesic agents generally …

New drug modalities offer life-saving benefits for patients through access to previously
undruggable targets. Yet these modalities pose a challenge for the pharmaceutical industry …

We explore the utility of bioengineered human tissues—individually or connected into
physiological units—for biological research. While much smaller and simpler than their …

Demyelinating diseases involve loss of myelin sheaths and eventually lead to neurological
problems. Unfortunately, the precise mechanisms remain unknown, and there are no …

Peripheral nerve injury is a prevalent clinical problem that often leads to lifelong disability
and reduced quality of life. Although peripheral nerves can regenerate, recovery after severe …

The craniofacial region consists of several different tissue types. These tissues are quite
commonly affected by traumatic/pathologic tissue loss which has so far been traditionally …