Reactive oxygen species (ROS) are metabolic byproducts that are necessary for
physiological function but can be toxic at high levels. Levels of these oxidative stressors …

Ageing is an inevitable event in the lifecycle of all organisms, characterized by progressive
physiological deterioration and increased vulnerability to death. Ageing has also been …

Accumulation of damaged mitochondria is a hallmark of aging and age-related
neurodegeneration, including Alzheimer's disease (AD). The molecular mechanisms of …

Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. Here we consider its roles in neuronal health and disease. We review …

Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …

Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

Introduction Blood–brain barrier (BBB) dysfunction may occur at the onset of Alzheimer's
disease (AD). Pericytes are a vital part of the neurovascular unit and the BBB, acting as …

Reactive oxygen and nitrogen species change cellular responses through diverse
mechanisms that are now being defined. At low levels, they are signalling molecules, and at …

Neurons are highly specialized post-mitotic cells that are inherently dependent on
mitochondria owing to their high bioenergetic demand. Mitochondrial dysfunction is …

Mitophagy is a highly specialized process to remove dysfunctional or superfluous
mitochondria through the macroautophagy/autophagy pathway, aimed at protecting cells …