Throughout its 40-year history, the field of gene therapy has been marked by many
transitions. It has seen great strides in combating human disease, has given hope to patients …

The frontiers of precision medicine have been revolutionized by the development of
Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR)/Cas9 as an editing …

The concept behind gene therapy is simple—by delivering corrective genetic material to the
cells of a patient the symptoms of disease can be alleviated. But seven years after the first …

The main objective in gene therapy is the development of efficient, non-toxic gene carriers
that can encapsulate and deliver foreign genetic materials into specific cell types such as …

Background/Aims: The activation of hepatic stellate cells is a key initiating event in hepatic
fibrogenesis. Although TGFβ1 is a potent inducer of collagen α1 (I) expression in vitro and …

Adenoviruses are attractive vectors for the delivery of foreign genes into mammalian cells for
gene therapy. However, current vectors retain many viral genes that, when expressed at low …

This article summarizes strategies to protect the liver from injuries caused by ischemia and
reperfusion. Three different sections (ie, surgical and pharmacologic strategies and gene …

Gene editing-based therapeutic strategies grant the power to override cell machinery and
alter faulty genes contributing to disease development like cancer. Nowadays, the principal …

The identification of monogenic and complex genes responsible for neurological disorders
requires new approaches for delivering therapeutic protein genes to significant numbers of …

Recombinant adenoviruses are an attractive vehicle for gene therapy to the lung in the
treatment of cystic fibrosis (CF). First-generation viruses deleted of E1a and E1b transduce …