Mechanisms of bone remodeling and therapeutic strategies in chronic apical periodontitis

X Luo, Q Wan, L Cheng, R Xu - Frontiers in cellular and infection …, 2022 - frontiersin.org
Chronic periapical periodontitis (CAP) is a typical oral disease in which periodontal
inflammation caused by an odontogenic infection eventually leads to bone loss …

Roles of non-canonical Wnt signalling pathways in bone biology

J Lojk, J Marc - International journal of molecular sciences, 2021 - mdpi.com
The Wnt signalling pathway is one of the central signalling pathways in bone development,
homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands …

DNAzyme nanoconstruct-integrated autonomously-adaptive coatings enhance titanium-implant osteointegration by cooperative angiogenesis and vessel remodeling

M Chen, M Li, X Ren, F Zhou, Y Li, L Tan, Z Luo… - ACS …, 2023 - ACS Publications
Orthopedic implants have a high failure rate due to insufficient interfacial osseointegration,
especially under osteoporotic conditions. Type H vessels are CD31+ EMCN+ capillaries …

Mesenchymal stem cells, bioactive factors, and scaffolds in bone repair: from research perspectives to clinical practice

S Stamnitz, A Klimczak - Cells, 2021 - mdpi.com
Mesenchymal stem cell-based therapies are promising tools for bone tissue regeneration.
However, tracking cells and maintaining them in the site of injury is difficult. A potential …

Loss of Notch signaling in skeletal stem cells enhances bone formation with aging

LH Remark, K Leclerc, M Ramsukh, Z Lin, S Lee… - Bone Research, 2023 - nature.com
Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age,
they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity …

Periosteal skeletal stem and progenitor cells in bone regeneration

S Perrin, C Colnot - Current Osteoporosis Reports, 2022 - Springer
Abstract Purpose of Review The periosteum, the outer layer of bone, is a major source of
skeletal stem/progenitor cells (SSPCs) for bone repair. Here, we discuss recent findings on …

Advances in animal models for studying bone fracture healing

H Gao, J Huang, Q Wei, C He - Bioengineering, 2023 - mdpi.com
Fracture is a common traumatic injury that is mostly caused by traffic accidents, falls, and
falls from height. Fracture healing is a long-term and complex process, and the mode of …

Regulation of bone homeostasis: signaling pathways and therapeutic targets

Z Wu, W Li, K Jiang, Z Lin, C Qian, M Wu, Y Xia… - MedComm, 2024 - Wiley Online Library
As a highly dynamic tissue, bone is continuously rebuilt throughout life. Both bone formation
by osteoblasts and bone resorption by osteoclasts constitute bone reconstruction …

The implications of cannabinoid-induced metabolic dysregulation for cellular differentiation and growth

T Podinić, G Werstuck, S Raha - International Journal of Molecular …, 2023 - mdpi.com
The endocannabinoid system (ECS) governs and coordinates several physiological
processes through an integrated signaling network, which is responsible for inducing …

[HTML][HTML] Bio-inspired liquid crystal gel with adjustable viscoelasticity to modulate cell behaviors and fate

K Liu, S Tang, L Zhu, W Wen, M Liu, H Li… - Composites Part B …, 2022 - Elsevier
Abstract Poly (D, l-lactide)(PDLLA) as a kind of bone repair material has been widely
concerned, however, the development of PDLLA material with remarkable cell affinity and …