Coding, or non-coding, that is the question

L Poliseno, M Lanza, PP Pandolfi - Cell Research, 2024 - nature.com
The advent of high-throughput sequencing uncovered that our genome is pervasively
transcribed into RNAs that are seemingly not translated into proteins. It was also found that …

The impact of microRNAs during inflammatory bowel disease: effects on the mucus layer and intercellular junctions for gut permeability

S Stiegeler, K Mercurio, MA Iancu, SC Corr - Cells, 2021 - mdpi.com
Research on inflammatory bowel disease (IBD) has produced mounting evidence for the
modulation of microRNAs (miRNAs) during pathogenesis. MiRNAs are small, non-coding …

The dopamine transporter gene SLC6A3: multidisease risks

MEA Reith, S Kortagere, CE Wiers, H Sun… - Molecular …, 2022 - nature.com
The human dopamine transporter gene SLC6A3 has been consistently implicated in several
neuropsychiatric diseases but the disease mechanism remains elusive. In this risk synthesis …

Non-coding RNAs in neuropathic pain

T Kalpachidou, KK Kummer, M Kress - Neuronal signaling, 2020 - portlandpress.com
Neuro-immune alterations in the peripheral and central nervous system play a role in the
pathophysiology of chronic pain in general, and members of the non-coding RNA (ncRNA) …

MicroRNAs targeted mTOR as therapeutic agents to improve radiotherapy outcome

S Taeb, D Rostamzadeh, SM Amini, M Rahmati… - Cancer cell …, 2024 - Springer
MicroRNAs (miRNAs) are small RNA molecules that regulate genes and are involved in
various biological processes, including cancer development. Researchers have been …

miProBERT: identification of microRNA promoters based on the pre-trained model BERT

X Wang, X Gao, G Wang, D Li - Briefings in bioinformatics, 2023 - academic.oup.com
Accurate prediction of promoter regions driving miRNA gene expression has become a
major challenge due to the lack of annotation information for pri-miRNA transcripts. This …

miRGTF-net: Integrative miRNA-gene-TF network analysis reveals key drivers of breast cancer recurrence

S Nersisyan, A Galatenko, V Galatenko, M Shkurnikov… - PLoS …, 2021 - journals.plos.org
Analysis of regulatory networks is a powerful framework for identification and quantification
of intracellular interactions. We introduce miRGTF-net, a novel tool for construction of miRNA …

MicroRNA‐34c‐5p exhibits anticancer properties in gastric cancer by targeting MAP2K1 to inhibit cell proliferation, migration, and invasion

Q Ma, Y Zhao, Z Li, W Gao, Y Xu, B Li… - BioMed Research …, 2022 - Wiley Online Library
Purpose. Gastric cancer (GC) is one of the deadliest digestive tract tumors worldwide,
existing studies suggest that dysregulated expression of microRNAs (miRNAs) plays an …

NOCICEPTRA: gene and microRNA signatures and their trajectories characterizing human iPSC‐derived nociceptor maturation

M Zeidler, KK Kummer, CL Schöpf… - Advanced …, 2021 - Wiley Online Library
Nociceptors are primary afferent neurons serving the reception of acute pain but also the
transit into maladaptive pain disorders. Since native human nociceptors are hardly available …

In vivo mechanism of the interaction between trimethylamine lyase expression and glycolytic pathways

Q Li, D Wu, Y Song, L Zhang, T Wang, X Chen… - Food & Function, 2025 - pubs.rsc.org
Recent studies confirmed that host–gut microbiota interactions modulate disease-linked
metabolite TMA production via TMA lyase. However, microbial enzyme production …