Spread and persistence of virulence and antibiotic resistance genes: a ride on the F plasmid conjugation module

G Koraimann - EcoSal plus, 2018 - Am Soc Microbiol
The F plasmid or F-factor is a large, 100-kbp, circular conjugative plasmid of Escherichia coli
and was originally described as a vector for horizontal gene transfer and gene …

The importance of the expendable: toxin–antitoxin genes in plasmids and chromosomes

R Díaz-Orejas, M Espinosa, CC Yeo - Frontiers in microbiology, 2017 - frontiersin.org
Toxin–antitoxin (TA) genes were first reported in plasmids and were considered expendable
genetic cassettes involved in the stable maintenance of the plasmid replicon by interfering …

Evolutionary paths that expand plasmid host-range: implications for spread of antibiotic resistance

W Loftie-Eaton, H Yano, S Burleigh… - Molecular biology …, 2016 - academic.oup.com
Abstract The World Health Organization has declared the emergence of antibiotic resistance
to be a global threat to human health. Broad-host-range plasmids have a key role in causing …

Crosstalk between vertical and horizontal gene transfer: plasmid replication control by a conjugative relaxase

F Lorenzo-Díaz, C Fernández-López… - Nucleic acids …, 2017 - academic.oup.com
Horizontal gene transfer is a key process in the evolution of bacteria and also represents a
source of genetic variation in eukaryotes. Among elements participating in gene transfer …

Stabilization of the Virulence Plasmid pSLT of Salmonella Typhimurium by Three Maintenance Systems and Its Evaluation by Using a New Stability Test

D Lobato-Márquez, L Molina-García… - Frontiers in molecular …, 2016 - frontiersin.org
Certain Salmonella enterica serovars belonging to subspecies I carry low-copy-number
virulence plasmids of variable size (50–90 kb). All of these plasmids share the spv operon …

Carriage of type II toxin-antitoxin systems by the growing group of IncX plasmids

P Bustamante, JR Iredell - Plasmid, 2017 - Elsevier
The stable maintenance of certain plasmids in bacterial populations has contributed
significantly to the current worldwide antibiotic resistance (AbR) emergency. IncX plasmids …

Successful Establishment of Plasmids R1 and pMV158 in a New Host Requires the Relief of the Transcriptional Repression of Their Essential rep Genes

JÁ Ruiz-Masó, LM Luengo, I Moreno-Córdoba… - Frontiers in …, 2017 - frontiersin.org
Although differing in size, encoded traits, host range, and replication mechanism, both
narrow-host-range theta-type conjugative enterobacterial plasmid R1 and promiscuous …

Antisense and yet sensitive: Copy number control of rolling circle‐replicating plasmids by small RNAs

R Pluta, M Espinosa - Wiley Interdisciplinary Reviews: RNA, 2018 - Wiley Online Library
Bacterial plasmids constitute a wealth of shared DNA amounting to about 20% of the total
prokaryotic pangenome. Plasmids replicate autonomously and control their replication by …

Targeted cancer cell killing by highly selective miRNA-triggered activation of a prokaryotic toxin–antitoxin system

A Turnbull, C Bermejo-Rodríguez… - ACS Synthetic …, 2019 - ACS Publications
Although not evolved to function in eukaryotes, prokaryotic toxin Kid induces apoptosis in
human cells, and this is avoided by coexpression of its neutralizing antitoxin, Kis. Inspired by …

Relaxasas conjugativas de la familia MOBv

C Fernández López - 2016 - docta.ucm.es
La conjugación es uno de los principales mecanismos de transferencia genética horizontal
entre bacterias. Este proceso consiste en el intercambio de material genético entre dos …