In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

The CRISPR-Cas system is commonly known for its ability to cleave DNA in a
programmable manner, which has democratized gene editing and facilitated recent …

While single-cell technologies have greatly advanced our comprehension of human brain
cell types and functions, studies including large numbers of donors and multiple brain …

Post-translational modifications (PTMs) on histones are a key source of regulation on
chromatin through impacting cellular processes, including gene expression. These PTMs …

Cancer cells frequently alter their lipids to grow and adapt to their environment,–. Despite
the critical functions of lipid metabolism in membrane physiology, signalling and energy …

Iron is essential to cells as a cofactor in enzymes of respiration and replication, however
without correct storage, iron leads to the formation of dangerous oxygen radicals. In yeast …

Organisms maintain metabolic homeostasis through the combined functions of small-
molecule transporters and enzymes. While many metabolic components have been well …

Blocking the import of nutrients essential for cancer cell proliferation represents a
therapeutic opportunity, but it is unclear which transporters to target. Here we report a …

Heme, an iron-containing tetrapyrrole in hemoproteins, including: hemoglobin, myoglobin,
catalase, cytochrome c, and cytochrome P450, plays critical physiological roles in different …

This study aimed to investigate the species diversity and genetic differentiation of the
genome of the main cultivated strains of Ganoderma in China. Population genomics …