Six genetic families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were described to
date. Inhibition of CAs has pharmacologic applications in the field of antiglaucoma …

Inhibition of the metalloenzyme carbonic anhydrase (CA; EC 4.2. 1.1) has pharmacologic
applications in the field of anti-glaucoma, anti-convulsant and anti-cancer agents. But …

Nitric oxide (NO) is one of the critical components of the vasculature, regulating key
signaling pathways in health. In macrovessels, NO functions to suppress cell inflammation …

The genome of the protozoan parasite Plasmodium falciparum, the causative agent of the
most lethal type of human malaria, contains a single gene annotated as encoding a carbonic …

Introduction: Of the 15 human carbonic anhydrase (CA, EC 4.2. 1.1) isoforms known to date,
for 11 the crystal structure is known. Many different classes of CA inhibitors (CAIs) were …

Introduction: Glaucoma is one of the major causes of blindness, affecting together with age-
related macular degeneration> 70 million people worldwide. One of the therapeutic options …

Introduction: The benzothiadiazines and high ceiling diuretics (hydrochlorothiazide,
hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide …

Journal of Enzyme Inhibition and Medicinal Chemistry to announce that the next CA meeting
will be held in Maastricht, the Netherlands, in 2015, but a mid-term meeting will be …

Introduction: The primary sulfonamide moiety is present in many clinically used drugs, such
as diuretics (furosemide, indapamide, chlorthalidone, thiazides); carbonic anhydrase (CA) …

Introduction: Carbonic anhydrases (CAs, EC 4.2. 1.1) exist as five genetically distinct
families (α, β, γ, δ and ζ) in organisms all over the phylogenetic tree. Due to the ubiquity of …