Mitochondria are remarkably dynamic organelles that migrate, divide and fuse. Cycles of
mitochondrial fission and fusion ensure metabolite and mitochondrial DNA mixing and …

Adult CNS neurons are typically described as permanently postmitotic but there is probably
nothing permanent about the neuronal cell cycle arrest. Rather, it appears that these highly …

The cellular oxidation and reduction (redox) environment is influenced by the production
and removal of reactive oxygen species (ROS). In recent years, several reports support the …

Traumatic brain injury (TBI) causes neuronal apoptosis, inflammation, and reactive
astrogliosis, which contribute to secondary tissue loss, impaired regeneration, and …

Five major types of intermediate filament (IF) proteins are expressed in mature neurons: the
three neurofilament proteins (NF‐L, NF‐M, and NF‐H), α‐internexin, and peripherin. While …

Apoptosis of neurons is indispensable to the normal development of the nervous system and
contributes to neuronal loss in neurologic injury and disease. Life and death decisions are …

Recent evidence indicates that cyclin-dependent kinases (CDKs, cdks) may be
inappropriately activated in several neurodegenerative conditions. Here, we report that cdk5 …

We reported previously that calpain-mediated Cdk5 activation is critical for mitochondrial
toxin-induced dopaminergic death. Here, we report a target that mediates this loss. Prx2, an …

The cellular pathways of motor neuronal injury have been investigated in the SOD1 G93A
murine model of familial amyotrophic lateral sclerosis (ALS) using laser-capture …

Cell cycle dysregulation has been implicated in the pathogenesis of neurodegenerative
disorders. Specialised function obligates neuronal cells to subsist in a quiescent state of cell …