Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

Covering: 1992 up to 2023 Since their discovery, lasso peptides went from peculiarities to
be recognized as a major family of ribosomally synthesized and post-translationally modified …

Changes in mitochondrial membrane permeability are closely associated with mitochondria-
mediated apoptosis. Antimicrobial peptides (AMPs), which have been found to enter cells to …

The biomarkers or receptors expressed on cancer cells and the targeting ligands with high
binding affinity for biomarkers play a key role in early detection and treatment of breast …

Bacteriocins, a class of antimicrobial peptide produced by bacteria, may offer a potential
alternative to traditional antibiotics, an important step towards mitigating the ever-increasing …

ABSTRACT Microcin J25 (MccJ25) uptake by Escherichia coli requires the outer membrane
receptor FhuA and the inner membrane proteins TonB, ExbD, ExbB, and SbmA. MccJ25 …

Microcin J25 has two targets in sensitive bacteria, the RNA polymerase, and the respiratory
chain through inhibition of cellular respiration. In this work, the effect of microcin J25 in E …

The overuse and misuse of traditional antimicrobial drugs have led to their weakened
effectiveness and the emergence of pathogenic bacterial resistance. Consequently, there …

Microcin J25, an antimicrobial lasso‐structure peptide, induces the opening of mitochondrial
permeability transition pores and the subsequent loss of cytochrome c. The microcin J25 …

Escherichia coli microcin J25 (MccJ25) is a lasso-peptide antibiotic comprising 21 l-amino
acid residues (G1-GAG-H5-VPEY-F10-VGIG-T15-PISF-Y20-G). MccJ25 has two …