Immune checkpoint blockade, which blocks inhibitory signals of T cell activation, has shown
tremendous success in treating cancer, although success still remains limited to a fraction of …

Human leukocyte antigen (HLA) can recognize and bind foreign peptides to present them to
specialized immune cells, then initiate an immune response. Computational prediction of the …

Natural killer (NK) cells represent a critical defense against viral infections and cancers. NK
cells require integration of activating and inhibitory NK cell receptors to detect target cells …

Neoantigen formation due to the interaction of drug molecules with human leukocyte antigen
(HLA)-peptide complexes can lead to severe hypersensitivity reactions. Flucloxacillin (FLX) …

Precision Neoantigen Discovery Using Large-scale Immunopeptidomes and Composite
Modeling of MHC Peptide Presentation Page 1 Precision Neoantigen Discovery Using …

The presentation of post-translationally modified (PTM) peptides by cell surface HLA
molecules has the potential to increase the diversity of targets for surveilling T cells …

Flucloxacillin is a β-lactam antibiotic associated with a high incidence of drug-induced liver
reactions. Although expression of human leukocyte antigen (HLA)-B* 57: 01 increases …

Significant advances in mass-spectroscopy (MS) have made it possible to investigate the
cellular immunopeptidome, a large collection of MHC-associated epitopes presented on the …

CD8+ T cells are a pivotal part of the immune response to viruses, playing a key role in
disease outcome and providing long-lasting immunity to conserved pathogen epitopes …

Neopeptide-based immunotherapy has been recognised as a promising approach for the
treatment of cancers. For neopeptides to be recognised by CD8+ T cells and induce an …