Albumin–drug interaction and its clinical implication

K Yamasaki, VTG Chuang, T Maruyama… - Biochimica et Biophysica …, 2013 - Elsevier
Background Human serum albumin acts as a reservoir and transport protein for endogenous
(eg fatty acids or bilirubin) and exogenous compounds (eg drugs or nutrients) in the blood …

Albumin, an interesting and functionally diverse protein, varies from 'native'to 'effective'

N Wu, T Liu, M Tian, C Liu, S Ma… - Molecular …, 2023 - spandidos-publications.com
Human serum albumins (HSAs) are synthesized in the liver and are the most abundant
proteins in plasma of healthy human. They play an important role in the pathophysiological …

Glycation of human serum albumin

J Anguizola, R Matsuda, OS Barnaby, KS Hoy, C Wa… - Clinica chimica acta, 2013 - Elsevier
Glycation involves the non-enzymatic addition of reducing sugars and/or their reactive
degradation products to amine groups on proteins. This process is promoted by the …

RAGE and its ligands: molecular interplay between glycation, inflammation, and hallmarks of cancer—a review

G Palanissami, SFD Paul - Hormones and Cancer, 2018 - Springer
Risk of cancer especially of colon, breast, and pancreas is high in diabetic and obese
patients, with potential involvement of augmented expression of RAGE (receptor for …

Modifications of human serum albumin and their binding effect

P Lee, X Wu - Current pharmaceutical design, 2015 - ingentaconnect.com
Human serum albumin (HSA) regulates the transport and availability of numerous chemical
compounds and molecules in the blood vascular system. While previous HSA research has …

[HTML][HTML] Comprehensive overview of human serum albumin glycation in diabetes mellitus

HY Qiu, NN Hou, JF Shi, YP Liu, CX Kan… - World journal of …, 2021 - ncbi.nlm.nih.gov
The presence of excess glucose in blood is regarded as a sweet hurt for patients with
diabetes. Human serum albumin (HSA) is the most abundant protein in human plasma …

Non-oncotic properties of albumin. A multidisciplinary vision about the implications for critically ill patients

R Ferrer, X Mateu, E Maseda, JC Yébenes… - Expert review of …, 2018 - Taylor & Francis
Introduction: Effective resuscitation with human albumin solutions is achieved with less fluid
than with crystalloid solutions. However, the role of albumin in today's critical care unit is …

Recent updates and advances in the use of glycated albumin for the diagnosis and monitoring of diabetes and renal, cerebro-and cardio-metabolic diseases

RV Giglio, B Lo Sasso, L Agnello, G Bivona… - Journal of Clinical …, 2020 - mdpi.com
Diabetes mellitus is a heterogeneous and dysmetabolic chronic disease in which the
laboratory plays a fundamental role, from diagnosis to monitoring therapy and studying …

Albumin-based transport of nonsteroidal anti-inflammatory drugs in mammalian blood plasma

MP Czub, KB Handing… - Journal of medicinal …, 2020 - ACS Publications
Every day, hundreds of millions of people worldwide take nonsteroidal anti-inflammatory
drugs (NSAIDs), often in conjunction with multiple other medications. In the bloodstream …

Structural and dynamic alteration of glycated human serum albumin in Schiff base and Amadori adducts: A molecular simulation study

S Sittiwanichai, D Japrung, T Mori… - The Journal of …, 2023 - ACS Publications
Human serum albumin (HSA) is a protein carrier in blood transporting metabolites and
drugs. Glycated HSA (GHSA) acts as a potential biomarker for diabetes. Thus, many …