Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

Electrophiles and reactive oxygen species (ROS) play a major role in modulating cellular
defense mechanisms as well as physiological functions, and intracellular signaling …

Abstract Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …

Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …

Alterations in α-synuclein dosage lead to familial Parkinson's disease (PD), and its
accumulation results in synucleinopathies that include PD, dementia with Lewy bodies …

Nrf2 is a basic region leucine-zipper transcription factor that plays a pivotal role in the
coordinated gene expression of antioxidant and detoxifying enzymes, promoting cell …

Parkinson's disease (PD) is the second most common neurodegenerative disorder which
affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of …

Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

A failure in redox homeostasis is a common hallmark of Alzheimer's Disease (AD) and
Parkinson's Disease (PD), two age-dependent neurodegenerative disorders (NDD), causing …