Biophysical and physiological origins of blood oxygenation level-dependent fMRI signals

SG Kim, S Ogawa - Journal of Cerebral Blood Flow & …, 2012 - journals.sagepub.com
After its discovery in 1990, blood oxygenation level-dependent (BOLD) contrast in functional
magnetic resonance imaging (fMRI) has been widely used to map brain activation in …

Electromagnetic fields and the blood–brain barrier

R Stam - Brain research reviews, 2010 - Elsevier
The mammalian blood–brain barrier (BBB) consists of endothelial cells, linked by tight
junctions, and the adjoining pericytes and extracellular matrix. It helps maintain a highly …

In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis

K Kirschbaum, JK Sonner, MW Zeller… - Proceedings of the …, 2016 - National Acad Sciences
Innate immune cells play a key role in the pathogenesis of multiple sclerosis and
experimental autoimmune encephalomyelitis (EAE). Current clinical imaging is restricted to …

[HTML][HTML] Monitoring innate immune cell dynamics in the glioma microenvironment by magnetic resonance imaging and multiphoton microscopy (MR-MPM)

K Karimian-Jazi, P Münch, A Alexander, M Fischer… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Glioblastoma is the most frequent, primary brain tumor that is characterized by a
highly immunosuppressive tumor microenvironment (TME). The TME plays a key role for …

On the origin of the MR image phase contrast: an in vivo MR microscopy study of the rat brain at 14.1 T

JP Marques, R Maddage, V Mlynarik, R Gruetter - Neuroimage, 2009 - Elsevier
Recent studies at high magnetic fields using the phase of gradient-echo MR images have
shown the ability to unveil cortical substructure in the human brain. To investigate the …

Is cortical vasculature functionally organized?

JL Gardner - Neuroimage, 2010 - Elsevier
The cortical vasculature is a well-structured and organized system, but the extent to which it
is organized with respect to the neuronal functional architecture is unknown. In particular …

Gradient‐echo and spin‐echo blood oxygenation level–dependent functional MRI at ultrahigh fields of 9.4 and 15.2 Tesla

SH Han, JP Son, HJ Cho, JY Park… - Magnetic resonance in …, 2019 - Wiley Online Library
Purpose Sensitivity and specificity of blood oxygenation level–dependent (BOLD) functional
MRI (fMRI) is sensitive to magnetic field strength and acquisition methods. We have …

Early Blood–Brain barrier disruption in ischemic stroke initiates Multifocally around Capillaries/Venules

A Hoffmann, T Dege, R Kunze, AS Ernst, H Lorenz… - Stroke, 2018 - Am Heart Assoc
Background and Purpose—Detection and localization of the early phase of blood–brain
barrier disruption (BBBD) in vivo during cerebral ischemia/reperfusion injury remain a major …

Correlated magnetic resonance imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis

MO Breckwoldt, J Bode, FT Kurz, A Hoffmann, K Ochs… - Elife, 2016 - elifesciences.org
Neoangiogenesis is a pivotal therapeutic target in glioblastoma. Tumor monitoring requires
imaging methods to assess treatment effects and disease progression. Until now mapping of …

Quantitative Susceptibility Mapping-Based Microscopy of Magnetic Resonance Venography (QSM-mMRV) for In Vivo Morphologically and Functionally Assessing …

MC Hsieh, CY Tsai, MC Liao, JL Yang, CH Su… - PLoS …, 2016 - journals.plos.org
Abnormal cerebral oxygenation and vessel structure is a crucial feature of stroke. An
imaging method with structural and functional information is necessary for diagnosis of …