Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness
and potential impact on cognition but also to its localized vertical integration of different …

Chronic stressful life events are risk factors for developing major depression, the
pathophysiology of which is strongly linked to impairments in serotonin (5-HT) …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

The brain is the key organ of the response to stress because it determines what is
threatening and, therefore, potentially stressful, as well as the physiological and behavioral …

Norepinephrine (NE) is a major monoamine neurotransmitter that has widespread effects
across multiple brain areas to regulate arousal and stress responses. The underlying …

It was long thought that no new neurons are added to the adult brain. Similarly,
neurotransmitter signaling was primarily associated with communication between …

Adult hippocampal neurogenesis is considered important for cognition. The integration of
newborn dentate gyrus granule cells into the existing network is regulated by afferent …

Aside from its roles in as a classical neurotransmitter involved in regulation of behavior,
noradrenaline (NA) has other functions in the CNS. This includes restricting the …

Adult hippocampal neurogenesis is a critical form of cellular plasticity that is greatly
influenced by neural activity. Among the neurotransmitters that are widely implicated in …

The neural stem cell niche defines a zone in which stem cells are retained after embryonic
development for the production of new cells of the nervous system. This continual supply of …