Tumors can be depicted as wounds that never heal, and are infiltrated by a large array of
inflammatory and immune cells. Tumor‐associated chronic inflammation is a hallmark of …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that suppress innate and adaptive immunity. MDSCs are present in many …

Epithelial–mesenchymal transition (EMT) has been implicated in various aspects of tumor
development, including tumor invasion and metastasis, cancer stemness, and therapy …

Interferons (IFNs) are pleiotropic cytokines critical for regulation of epithelial cell functions
and for immune system regulation. In cancer, IFNs contribute to tumor-intrinsic and-extrinsic …

Myeloid-derived suppressor cells (MDSCs) constitute a vast population of immature myeloid
cells implicated in various conditions. Most notably, their role in cancer is of great …

The etiology of ulcerative colitis is poorly understood and is likely to involve perturbation of
the complex interactions between the mucosal immune system and the commensal bacteria …

Despite recent major clinical breakthroughs in human cancer immunotherapy including the
use of checkpoint inhibitors and engineered T cells, important challenges remain, including …

Although myeloid-derived suppressor cells (MDSCs) have been demonstrated to contribute
to tumor initiation, progression and metastasis, however, which MDSC subsets are …

How to effectively transform the pro-oncogenic tumor microenvironments (TME) surrounding
a tumor into an anti-tumoral never fails to attract people to study. Small interfering RNA …

The tumor microenvironment consists of an immunosuppressive niche created by the
complex interactions between cancer cells and surrounding stromal cells. A critical …