Antibodies are powerful modulators of ongoing and future B cell responses. While the
concept of antibody feedback has been appreciated for over a century, the topic has seen a …

Memory B cells are comprised of unswitched (CD27+ IgD+) and switched (CD27+ IgD-)
subsets. The origin and function of unswitched human memory B cells are debated in the …

Acetylcholine is produced in the spleen in response to vagus nerve activation; however, the
effects on antibody production have been largely unexplored. Here, we use a chronic vagus …

BACKGROUND: Doxorubicin is an effective chemotherapeutic agent, but its use is limited by
acute and chronic cardiotoxicity. Exercise training has been shown to protect against …

Moderate-to-severe systemic lupus erythematosus (SLE) is characterized by extensive
autoantibody deposition and persistent autoinflammation. As the existing animal models are …

Glaesserella parasuis (G. parasuis) can elicit meningitis in pigs; however, the pathogenic
mechanisms of meningitis induced by G. parasuis remain unclear. Long non-coding RNAs …

Messenger RNA (mRNA)‐based therapies have emerged as a revolutionary strategy for
treating various diseases. In autoimmune diseases like rheumatoid arthritis (RA), targeted …

The pathophysiology of sickle cell disease (SCD) is characterized by hemolytic anemia and
vaso-occlusion, although its impact on the adaptive immune responses remains …

Granulomatosis with polyangiitis (GPA) is a B-cell-mediated, relapsing, autoimmune
disease. There is a need for novel therapeutic approaches and relapse markers to achieve …

Despite their relative abundance, the role of B lympho-cytes (B-cells) in healthy murine
myocardial tissue has not been elucidated. Constituting≈ 20% of myocardial immune …