This review summarizes the trends in the formation of complex or not so complex
heterocyclic structures through 1, 3-dipolar cycloadditions of azomethine ylides. Diastereo …

Spirocompounds constitute an important class of organic frameworks enveloping numerous
pharmacological activities, among them, the promising anticancer potential of …

Objective The spirooxindole heterocyclic scaffold is found in many natural products and has
been identified as an important bioactive agent. Background Over the past few decades …

This review aimed at summarizing the literature pertaining to the biological activities of
pyrrolidine alkaloids and their derivatives obtained from various sources. For this purpose …

Abstract Series of piperidone-salicylate conjugates were synthesized through the reaction of
3E, 5E-bis (arylidene)-4-piperidones with the appropriate acid chloride of acetylsalicylate in …

Novel, quinolone–fluoroquinolone conjugates 10a–f, 11a–f, 13a–f and 14a–f with amino
acid linkers were synthesized in good yields utilizing benzotriazole chemistry. Antibacterial …

Abstract Sets of 3-alkenyl-2-oxindoles (6, 10, 13) were synthesized in a facile synthetic
pathway through acid dehydration (EtOH/HCl) of the corresponding 3-hydroxy-2 …

Despite the decreasing trend in mortality from colorectal cancer, this disease still remains
the third most common cause of death from cancer. In the present study, we investigated the …

New sets of ibuprofen and indomethacin conjugates comprising triazolyl heterocycle were
synthesized via click chemistry, adopting an optimized protocol through the molecular …

Novel fluoroquinolone–pyrazine conjugates 7a–h with amino acid linkers were synthesized
in good yields utilizing benzotriazole chemistry. Antimicrobial bioassay showed that the …