BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely
acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes …

Epigenetics has been defined as 'the structural adaptation of chromosomal regions so as to
register, signal or perpetuate altered activity states.'Currently, several classes of anticancer …

Epigenetic proteins are intently pursued targets in ligand discovery. So far, successful efforts
have been limited to chromatin modifying enzymes, or so-called epigenetic 'writers' and …

Abstract Bromodomain protein 4 (BRD4) is a chromatin-binding protein implicated in cancer
and autoimmune diseases that functions as a scaffold for transcription factors at promoters …

The bromodomain is a highly conserved motif of 110 amino acids that is bundled into four
anti-parallel α-helices and found in proteins that interact with chromatin, such as …

BRD4, the most extensively studied member of the BET family, is an epigenetic regulator
that localizes to DNA via binding to acetylated histones and controls the expression of …

Bromodomains have emerged as attractive candidates for the development of inhibitors
targeting gene transcription. Inhibitors of the bromo and extraterminal (BET) family recently …

Bromodomain protein 4 (Brd4) plays critical roles in development, cancer progression, and
virus-host pathogenesis. To gain mechanistic insight into the various biological functions of …

Transcription factors and chromatin-remodeling complexes are key determinants of
embryonic stem cell (ESC) identity. Here, we demonstrate that BRD4, a member of the …

Bromo and extra terminal (BET) proteins (BRD2, BRD3, BRD4, and BRDT) are
transcriptional regulators required for efficient expression of several growth promoting and …