Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …

Background: Affective and emotional symptoms such as depression, anxiety, euphoria, and
irritability are common neuropsychiatric symptoms (NPS) in pre-dementia and cognitively …

Background Hippocampal volume reduction is the most replicated finding in neuroimaging
studies of major depressive disorder (MDD). Varying hippocampal volume definition is a …

As the population ages, the economic and societal impacts of neurodegenerative and
neuropsychiatric disorders are expected to rise sharply. Like dementia, late-life depressive …

Reduced hippocampal volume has been reported in depression and may be involved in the
aetiology of depressive symptoms and vulnerability to depressive relapse. Neuroplasticity …

Abstract Introduction The Cognitive Debt hypothesis proposes that repetitive negative
thinking (RNT), a modifiable process common to many psychological risk factors for …

Objective: To determine whether neuroimaging biomarkers of amyloid-β (Aβ) and
neurodegeneration (ND) are associated with greater self-reported subjective cognitive …

Background Major depressive disorder is a serious psychiatric illness with a highly variable
and heterogeneous clinical course. Due to the lack of consistent data from previous studies …

Background We systematically reviewed and meta-analyzed the association of late-life
depression (LLD) with hippocampal volume (HCV) and total brain volume (TBV), and of …

Animal and human autopsy studies suggest that subfields of the hippocampal formation are
differentially affected by neuropsychiatric diseases. Therefore, subfield volumes may be …