Dysphagia in Parkinson's disease

I Suttrup, T Warnecke - Dysphagia, 2016 - Springer
More than 80% of patients with Parkinson's disease (PD) develop dysphagia during the
course of their disease. Swallowing impairment reduces quality of life, complicates …

[HTML][HTML] Drooling in Parkinson's disease: a review

P Srivanitchapoom, S Pandey, M Hallett - Parkinsonism & related disorders, 2014 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disease causing both motor and non-
motor symptoms. Drooling, an excessive pooling and spillover of saliva out of the oral cavity …

Evidence for early and progressive ultrasonic vocalization and oromotor deficits in a PINK1 gene knockout rat model of Parkinson's disease

LM Grant, CA Kelm‐Nelson, BL Hilby… - Journal of …, 2015 - Wiley Online Library
Parkinson's disease (PD) is a progressive neurodegenerative disease that leads to a wide
range of motor and nonmotor deficits. Specifically, voice and swallow deficits manifest early …

Animal behavioral assessments in current research of Parkinson's disease

T Asakawa, H Fang, K Sugiyama, T Nozaki… - Neuroscience & …, 2016 - Elsevier
Abstract Parkinson's disease (PD), a neurodegenerative disorder, is traditionally classified
as a movement disorder. Patients typically suffer from many motor dysfunctions. Presently …

Animal models for dysphagia studies: what have we learnt so far

RZ German, AW Crompton, FDH Gould, AJ Thexton - Dysphagia, 2017 - Springer
Research using animal models has contributed significantly to realizing the goal of
understanding dysfunction and improving the care of patients who suffer from dysphagia …

Adapting human videofluoroscopic swallow study methods to detect and characterize dysphagia in murine disease models

TE Lever, SM Braun, RT Brooks… - Journal of …, 2015 - pmc.ncbi.nlm.nih.gov
This study adapted human videofluoroscopic swallowing study (VFSS) methods for use with
murine disease models for the purpose of facilitating translational dysphagia research …

Videofluoroscopic validation of a translational murine model of presbyphagia

TE Lever, RT Brooks, LA Thombs, LL Littrell, RA Harris… - Dysphagia, 2015 - Springer
Presbyphagia affects approximately 40% of otherwise healthy people over 60 years of age.
Hence, it is a condition of primary aging rather than a consequence of primary disease. This …

Age-related alterations in swallowing biomechanics

H Kletzien, MJ Cullins, NP Connor - Experimental gerontology, 2019 - Elsevier
Background Aging rodent models allow for the discovery of underlying mechanisms of
cranial muscle dysfunction. Methods are needed to allow quantification of complex …

Pink1 −/− Rats Show Early-Onset Swallowing Deficits and Correlative Brainstem Pathology

KP Cullen, LM Grant, CA Kelm-Nelson, AFL Brauer… - Dysphagia, 2018 - Springer
Parkinson disease (PD) compromises oropharyngeal swallowing, which negatively affects
quality of life and contributes to aspiration pneumonia. Dysphagia often begins early in the …

Reduced tongue force and functional swallowing changes in a rat model of post stroke dysphagia

MJ Cullins, NP Connor - Brain research, 2019 - Elsevier
Purpose Dysphagia is a common problem after stroke that is often associated with tongue
weakness. However, the physiological mechanisms of post-stroke tongue muscle weakness …