Somatic mutations in cancer genes have been detected in clonal expansions across healthy
human tissue, including in clonal hematopoiesis. However, because mutated and wild-type …

Recent studies have provided several insights into acute myeloid leukemia. Studies based
on molecular biology have identified eight functional mutations involved in leukemogenesis …

The history of clonal hematopoiesis (CH) research is punctuated by several seminal
discoveries that have forged our understanding of cancer development. The clever …

The bone marrow (BM) stroma in myeloid neoplasms is altered and it is hypothesized that
this cell compartment may also harbor clonal somatically acquired mutations. By exome …

The associations between rheumatologic disorders and malignancy have been well
described in the literature. The causes vary from rheumatic comorbidity, unchecked chronic …

The available evidence has been proving the utility of somatic mutational analysis in
patients with unexplained cytopenia, as well as in those receiving a diagnosis of myeloid …

Immune dysregulation has been highlighted as a key player in the pathogenesis of
myelodysplastic syndromes (MDS), but little is known about cytokine profiles in patients with …

Cancer and cardiovascular diseases are two major health threats to humanity. Survivors of
cancer have a higher risk of developing and dying from cardiovascular disease compared to …

This series of research papers explores the influence of various stressors on genotype–
phenotype relationships in the context of premalignant and malignant hematologic …

Dissecting functional consequences of gene mutations contributes to understanding disease
development and identifying potential treatment strategies. Mutations in epigenetic …