[HTML][HTML] Recent advances in chalcone-triazole hybrids as potential pharmacological agents
Molecular hybridization is one of the recent strategies to synthesize a novel hybrid
compound by combining two or more pharmacophoric units. Being a linkage process, it …
compound by combining two or more pharmacophoric units. Being a linkage process, it …
Development of 1, 2, 3-triazole hybrids as multi-faced anticancer agents co-targeting EGFR/mTOR pathway and tubulin depolymerization
Abstract Novel 1, 2, 3-triazole hybrids bearing various substituents have been synthesized
as potential anticancer agents. Ligand-based approach has been adopted to design these …
as potential anticancer agents. Ligand-based approach has been adopted to design these …
[HTML][HTML] Targeting Hypoglycemic Natural Products from the Cloud Forest Plants Using Chemotaxonomic Computer-Assisted Selection
CI Mayo-Montor, A Vidal-Limon… - International Journal of …, 2024 - mdpi.com
The cloud forest (CF), a hugely biodiverse ecosystem, is a hotspot of unexplored plants with
potential for discovering pharmacologically active compounds. Without sufficient …
potential for discovering pharmacologically active compounds. Without sufficient …
[HTML][HTML] Eugenol derivatives containing 1, 2, 3-triazole-chalcone hybrids for shikimate kinase inhibition
Eugenol, a primary component of clove oil, is a compound of considerable interest in
medicinal chemistry due to its demonstrated potential as an effective agent in various …
medicinal chemistry due to its demonstrated potential as an effective agent in various …
Synthesis, isomorphism, and polymorphism of new (2E, 4E)-1-(5-methyl-1-aryl-1H-1, 2, 3-triazol-4-yl)-5-phenylpenta-2, 4-dien-1-ones
Abstract The Claisen–Schmidt condensation of 1-aryl-4-acetyl-5-methyl-1, 2, 3-triazoles and
trans-cinnamaldehyde in ethanolic sodium hydroxide (10%) at room temperature gave (2E …
trans-cinnamaldehyde in ethanolic sodium hydroxide (10%) at room temperature gave (2E …
Discovery of thymol-fused chalcones as new competitive -glucosidase inhibitors: Design, synthesis, biological evaluation, and molecular modeling studies
A Danova, E Hermawati, W Chavasiri… - … in Science and …, 2024 - cst.kipmi.or.id
This study aims to synthesize and evaluate the inhibitory activity of thymol derivatives
targeting?-glucosidase using in vitro and in silico studies. Ten thymol derivatives (2-11) …
targeting?-glucosidase using in vitro and in silico studies. Ten thymol derivatives (2-11) …
Synthesis of Dihydropyrimidinones via Biginelli Reaction by Using Molecular Iodine as Environmentally Friendly Catalyst
A Fadlan, LY Pratama, YA Ilfahmi… - … Series: Earth and …, 2025 - iopscience.iop.org
Abstract The synthesis of 3, 4-dihydropyrimidine-2-ones has been the focus of much interest
since they exhibited various biological activities with pharmacology potentials (antibacterial …
since they exhibited various biological activities with pharmacology potentials (antibacterial …
Computational Assessment of Thiazole Derivatives as Potential Antidiabetic Agents through Molecular Docking Studies
JMK Babu, KN Arathi, S Lakshmi… - Asian Journal of …, 2024 - search.proquest.com
Understanding the precise location and binding mechanism of a ligand allows for the
rational design of modifications to enhance protein-ligand interaction, increase activity, and …
rational design of modifications to enhance protein-ligand interaction, increase activity, and …