Glaucoma is the leading cause of global irreversible blindness, necessitating research for
new, more efficacious treatment options than currently exist. Trabecular meshwork (TM) cells …

The corneal endothelium located on the posterior corneal surface is responsible for
regulating stromal hydration. This is contributed by a monolayer of corneal endothelial cells …

Rho kinase inhibitors (ROCKi) have attracted growing multidisciplinary interest, particularly
in Ophthalmology where the question as to how they promote corneal endothelial healing …

Primary open-angle glaucoma (POAG) is currently the most prevalent cause of irreversible
blindness globally. To date, few in vitro models that can faithfully recapitulate the complex …

Studies from our laboratory have suggested that activation of αvβ3 integrin-mediated
signaling could contribute to the fibrotic-like changes observed in primary open angle …

Purpose To provide an overview of the existing alternative models for studying trabecular
meshwork (TM). Methods Literature review. Results The TM is a complex tissue that …

Stem cell-based therapy to restore the function of abnormal trabecular meshwork (TM) and
decrease intraocular pressure (IOP) provides a novel approach to treat open-angle …

Human corneal endothelial cells are notorious for their restricted proliferative ability in vivo
and in vitro. Hence, injury or dysfunction of these cells may easily result in blindness …

Glaucoma is one of the leading causes of vision loss worldwide, characterised with
irreversible optic nerve damage and progressive vision loss. Primary open-angle glaucoma …

Purpose of review In this review, we overview the pathophysiology of primary open-angle
glaucoma as it relates to the trabecular meshwork (TM), exploring modes of TM dysfunction …