Osteosarcoma is the most common primary malignant tumour of the bone. Osteosarcoma
incidence is bimodal, peaking at 18 and 60 years of age, and is slightly more common in …

Wnt signaling affects both bone modeling, which occurs during development, and bone
remodeling, which is a lifelong process involving tissue renewal. Wnt signals are especially …

Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

Patients who develop osteosarcoma in 2017 receive treatment that remains essentially
unchanged since the 1970s. Outcomes likewise remain largely unimproved. Large …

It has been difficult to identify the molecular features central to the pathogenesis of
osteosarcoma owing to a lack of understanding of the cell or origin, the absence of …

Osteosarcoma is the most common malignant bone tumour, with a peak incidence in
children and young adolescents, suggesting a role of rapid bone growth in its pathogenesis …

Ezrin is a multifunctional protein that connects the actin cytoskeleton to the extracellular
matrix through transmembrane proteins. High ezrin expression is associated with lung …

Aberrant activation of the Wnt/β-catenin signaling pathway promotes osteosarcoma
tumorigenesis and metastasis. In this study, we tested the hypothesis that osteosarcoma …

The tumor microenvironment has an important role in cancer progression. Here we show
that miR-148a is downregulated in 15 out of 16 samples (94%) of cancer-associated …

WNT10B, a member of the WNT family of secreted glycoproteins, activates the WNT/β-
catenin signaling cascade to control proliferation, stemness, pluripotency, and cell fate …