The IL-17 family of cytokines in health and disease
The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A
through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 th …
through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 th …
IL-17 receptor–based signaling and implications for disease
IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes,
including host defense, tissue repair, the pathogenesis of inflammatory disease and the …
including host defense, tissue repair, the pathogenesis of inflammatory disease and the …
[HTML][HTML] Targeted immunotherapy for autoimmune disease
SM Jung, WU Kim - Immune network, 2022 - ncbi.nlm.nih.gov
In the past few decades, biological drugs and small molecule inhibitors targeting
inflammatory cytokines, immune cells, and intracellular kinases have become the standard …
inflammatory cytokines, immune cells, and intracellular kinases have become the standard …
IL-17 signaling: the yin and the yang
Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While
the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL …
the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL …
The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing
Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major
revision of the TH subset paradigm and substantial progress has been made in deciphering …
revision of the TH subset paradigm and substantial progress has been made in deciphering …
IL-17 family: cytokines, receptors and signaling
C Gu, L Wu, X Li - Cytokine, 2013 - Elsevier
Abstract The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A–F, plays
crucial roles in host defense against microbial organisms and in the development of …
crucial roles in host defense against microbial organisms and in the development of …
Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice
F Meng, K Wang, T Aoyama, SI Grivennikov, YH Paik… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Interleukin (IL)-17 signaling has been implicated in lung and skin
fibrosis. We examined the role of IL-17 signaling in the pathogenesis of liver fibrosis in mice …
fibrosis. We examined the role of IL-17 signaling in the pathogenesis of liver fibrosis in mice …
Structure and signalling in the IL-17 receptor family
SL Gaffen - Nature Reviews Immunology, 2009 - nature.com
Abstract Interleukin-17A (IL-17A), the hallmark cytokine of the newly defined T helper 17
(TH17) cell subset, has important roles in protecting the host against extracellular …
(TH17) cell subset, has important roles in protecting the host against extracellular …
[HTML][HTML] Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis
A Chiricozzi, E Guttman-Yassky… - Journal of Investigative …, 2011 - Elsevier
Psoriasis is a complex inflammatory disease mediated by tumor necrosis factor (TNF)-α and
cytokines secreted by specialized T-cell populations, eg, IL-17, IL-22, and IFN-γ. The …
cytokines secreted by specialized T-cell populations, eg, IL-17, IL-22, and IFN-γ. The …
Interleukin-17 as a key player in neuroimmunometabolism
Abstract In mammals, interleukin (IL)-17 cytokines are produced by innate and adaptive
lymphocytes. However, the IL-17 family has widespread expression throughout evolution …
lymphocytes. However, the IL-17 family has widespread expression throughout evolution …