The bioactive peptides galanin, spexin and kisspeptin have a common ancestral origin and
their pathophysiological roles are increasingly the subject of investigation. Evidence …

1. A TP-Regulated K+-Channels (KA TP Channels)(a) Single-channel conductance and
voltage dependence (b) Permeability and selectivity (c) Kinetics (d) Effects of. 4 TP (i) …

A K-CHANNEL inhibited by intracellular ATP was first described in cardiac muscle [1]. It has
since become clear that such channels (K-ATP channels) occur also in other tissues as a …

Since the discovery of galanin (GAL) in 1983 (Tatemoto et al., 1983) numerous anatomical,
physiological and pharmacological investigations have demonstrated that the peptide is …

Neurotransmitters and hormones such as somatostatin, galanin, and adrenalin reduce
insulin secretion. Their inhibitory action involves direct interference with the exocytotic …

The endogenous inhibitory role of the neuropeptide galanin in pain transmission and spinal
cord excitability was demonstrated by the use of a high-affinity galanin receptor antagonist …

Insulin secretion has been studied in isolated rat pancreatic islets under stringent Ca (2+)-
depleted, Ca (2+)-free conditions. Under these conditions, the effect of 16.7 mM glucose to …

Obesity is the main risk factor for the development of metabolic syndrome. Endogenous
cannabinoids act on the cannabinoid type 1 (CB1) receptor, a GPCR, and stimulate appetite …

The maintenance of homeostatic blood glucose concentrations is a complex, integrated
process mainly regulated by a single molecule-insulin. This anti-hyperglycemia hormone …

Norepinephrine has for many years been known to have three major effects on the
pancreatic β-cell which lead to the inhibition of insulin release. These are activation of K+ …