Genetically encoded sensors towards imaging cAMP and PKA activity in vivo
Cyclic adenosine monophosphate (cAMP) is a universal second messenger that plays a
crucial role in diverse biological functions, ranging from transcription to neuronal plasticity …
crucial role in diverse biological functions, ranging from transcription to neuronal plasticity …
Methods for analyzing neuronal structure and activity in Caenorhabditis elegans
The model research animal Caenorhabditis elegans has unique properties making it
particularly advantageous for studies of the nervous system. The nervous system is …
particularly advantageous for studies of the nervous system. The nervous system is …
Tunable transcription factor library for robust quantification of regulatory properties in Escherichia coli
Predicting the quantitative regulatory function of transcription factors (TFs) based on factors
such as binding sequence, binding location, and promoter type is not possible. The …
such as binding sequence, binding location, and promoter type is not possible. The …
Real‐Time, Non‐Invasive Monitoring of Neuronal Differentiation Using Intein‐Enabled Fluorescence Signal Translocation in Genetically Encoded Stem Cell‐Based …
Real‐time and non‐invasive monitoring of neuronal differentiation helps to increase
understanding of neuronal development and develop stem cell therapies for …
understanding of neuronal development and develop stem cell therapies for …
Beyond a Transmission Cable—New Technologies to Reveal the Richness in Axonal Electrophysiology
JC Mateus, MM Sousa, J Burrone… - Journal of …, 2024 - Soc Neuroscience
The axon is a neuronal structure capable of processing, encoding, and transmitting
information. This assessment contrasts with a limiting, but deeply rooted, perspective where …
information. This assessment contrasts with a limiting, but deeply rooted, perspective where …
Theranostic system for ratiometric fluorescence monitoring of peptide-guided targeted drug delivery
A Rozovsky, TM Ebaston, A Zaporozhets… - RSC …, 2019 - pubs.rsc.org
Conjugation of an anticancer drug with a cancer-specific carrier and a fluorescent dye to
form a theranostic system enables real time monitoring of targeted drug delivery (TDD) …
form a theranostic system enables real time monitoring of targeted drug delivery (TDD) …
Dual-dye systems comprising activatable fluorescein dye and hydrophobic or hydrophilic Cy5 reference fluorophore for ratiometric drug delivery monitoring
D Poplinger, A Bazylevich, M Bokan… - … of Photochemistry and …, 2021 - Elsevier
Ratiometric fluorescence detection in biological samples in vitro and in vivo mitigates
several issues in conventional single-signal measurements such as light absorption and …
several issues in conventional single-signal measurements such as light absorption and …
Single cell in vivo optogenetic stimulation by two-photon excitation fluorescence transfer
Optogenetic manipulation with single-cell resolution can be achieved by two-photon
excitation. However, this frequently requires relatively high laser powers. Here, we …
excitation. However, this frequently requires relatively high laser powers. Here, we …
Computational framework for single-cell spatiotemporal dynamics of optogenetic membrane recruitment
We describe a modular computational framework for analyzing cell-wide spatiotemporal
signaling dynamics in single-cell microscopy experiments that accounts for the experiment …
signaling dynamics in single-cell microscopy experiments that accounts for the experiment …
[HTML][HTML] Perturbed Ca2+-dependent signaling of DYT2 hippocalcin mutant as mechanism of autosomal recessive dystonia
A recent report of autosomal-recessive primary isolated dystonia (DYT2 dystonia) identified
mutations in HPCA, a gene encoding a neuronal calcium sensor protein, hippocalcin …
mutations in HPCA, a gene encoding a neuronal calcium sensor protein, hippocalcin …