RNA modification: mechanisms and therapeutic targets

L Qiu, Q Jing, Y Li, J Han - Molecular Biomedicine, 2023 - Springer
RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …

Cardiac remodelling–Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the …

A González, AM Richards, RA de Boer… - European journal of …, 2022 - Wiley Online Library
Cardiac remodelling refers to changes in left ventricular structure and function over time,
with a progressive deterioration that may lead to heart failure (HF) development (adverse …

Microbiome and metabolome features of the cardiometabolic disease spectrum

S Fromentin, SK Forslund, K Chechi… - Nature medicine, 2022 - nature.com
Previous microbiome and metabolome analyses exploring non-communicable diseases
have paid scant attention to major confounders of study outcomes, such as common, pre …

RNA modifications in cardiovascular diseases, the potential therapeutic targets

Y Wu, S Zhan, Y Xu, X Gao - Life Sciences, 2021 - Elsevier
More than one hundred RNA modifications decorate the chemical and topological properties
of these ribose nucleotides, thereby executing their biological functions through post …

Metabolomic profiles and heart failure risk in black adults: insights from the Jackson Heart Study

UA Tahir, DH Katz, T Zhao, D Ngo, DE Cruz… - Circulation: Heart …, 2021 - Am Heart Assoc
Background: Heart failure (HF) is a heterogeneous disease characterized by significant
metabolic disturbances; however, the breadth of metabolic dysfunction before the onset of …

Decoding the 'fifth'nucleotide: impact of RNA pseudouridylation on gene expression and human disease

A Jalan, PJ Jayasree, P Karemore, KP Narayan… - Molecular …, 2023 - Springer
Cellular RNAs, both coding and noncoding are adorned by> 100 chemical modifications,
which impact various facets of RNA metabolism and gene expression. Very often …

Candida albicans accelerates atherosclerosis by activating intestinal hypoxia-inducible factor2α signaling

X Wang, S Zhou, X Hu, C Ye, Q Nie, K Wang, S Yan… - Cell Host & Microbe, 2024 - cell.com
The gut microbiota is closely linked to atherosclerosis. However, the role of intestinal fungi,
essential members of the complex microbial community, in atherosclerosis is poorly …

[HTML][HTML] RNA modifications in aging-associated cardiovascular diseases

X Yang, P Gokulnath, HI Lehmann, Z Hou… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide that
bears an enormous healthcare burden and aging is a major contributing factor to CVDs …

Combined exposure to decabromodiphenyl ether and nano zero-valent iron aggravated oxidative stress and interfered with metabolism in earthworms

Y Han, S Ling, S Hu, G Shen, H Zhang… - Science of The Total …, 2024 - Elsevier
Abstract Decabromodiphenyl ether (BDE-209) is a common brominated flame retardant in
electronic waste, and nano zero-valent iron (nZVI) is a new material in the field of …

Joint modeling approaches for censored predictors due to detection limits with applications to metabolites data

P Ye, S Bai, W Tang, H Feng, X Qiao, S Tu… - Statistics in …, 2024 - Wiley Online Library
Measures of substance concentration in urine, serum or other biological matrices often have
an assay limit of detection. When concentration levels fall below the limit, exact measures …