Cellular sources of TSPO expression in healthy and diseased brain

E Nutma, K Ceyzériat, S Amor, S Tsartsalis… - European journal of …, 2021 - Springer
The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …

Translocator protein (18 kDa)(TSPO) as a therapeutic target for neurological and psychiatric disorders

R Rupprecht, V Papadopoulos, G Rammes… - Nature reviews Drug …, 2010 - nature.com
Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …

The mitochondrial permeability transition pore: a mystery solved?

P Bernardi - Frontiers in physiology, 2013 - frontiersin.org
The permeability transition (PT) denotes an increase of the mitochondrial inner membrane
permeability to solutes with molecular masses up to about 1500 Da. It is presumed to be …

[HTML][HTML] Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization

TR Guilarte, AN Rodichkin, JL McGlothan… - Pharmacology & …, 2022 - Elsevier
Abstract Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …

Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and …

H Li, V Papadopoulos - Endocrinology, 1998 - academic.oup.com
In steroid-synthesizing cells, like the MA-10 mouse tumor Leydig cells, the peripheral-type
benzodiazepine receptor (PBR) is an outer mitochondrial membrane protein involved in the …

Regulation of the acute production of steroids in steroidogenic cells

DM Stocco, BJ Clark - Endocrine reviews, 1996 - academic.oup.com
Introduction The steroid hormones constitute a very important class of compounds and are
present in most species. The hormones that are synthesized in the adrenal gland, namely …

Localized effects of cAMP mediated by distinct routes of protein kinase A

K Taskén, EM Aandahl - Physiological reviews, 2004 - journals.physiology.org
Taskén, Kjetil, and Einar Martin Aandahl. Localized Effects of cAMP Mediated by Distinct
Routes of Protein Kinase A. Physiol Rev 84: 137–167, 2004; 10.1152/physrev. 00021.2003 …

The peripheral benzodiazepine binding site in the brain in multiple sclerosis: Quantitative in vivo imaging of microglia as a measure of disease activity

RB Banati, J Newcombe, RN Gunn, A Cagnin… - Brain, 2000 - academic.oup.com
This study identifies by microautoradiography activated microglia/macrophages as the main
cell type expressing the peripheral benzodiazepine binding site (PBBS) at sites of active …

Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier.

MW McEnery, AM Snowman… - Proceedings of the …, 1992 - National Acad Sciences
The mitochondrial benzodiazepine receptor (mBzR) has been solubilized with retention of
reversible ligand binding, and the associated subunits were characterized. mBzR comprises …

Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair

MK Chen, TR Guilarte - Pharmacology & therapeutics, 2008 - Elsevier
For over 15 years, the peripheral benzodiazepine receptor (PBR), recently named
translocator protein 18 kDa (TSPO) has been studied as a biomarker of reactive gliosis and …