Mineralized collagen fibrils: An essential component in determining the mechanical behavior of cortical bone

L Al-Qudsy, YW Hu, H Xu, PF Yang - ACS Biomaterials Science & …, 2023 - ACS Publications
Bone comprises mechanically different materials in a specific hierarchical structure.
Mineralized collagen fibrils (MCFs), represented by tropocollagen molecules and …

A review on experimental and numerical investigations of cortical bone fracture

A Kumar, R Ghosh - … , Part H: Journal of Engineering in …, 2022 - journals.sagepub.com
This paper comprehensively reviews the various experimental and numerical techniques,
which were considered to determine the fracture characteristics of the cortical bone. This …

Parametric modeling of biomimetic cortical bone microstructure for additive manufacturing

JA Robles-Linares, E Ramírez-Cedillo, HR Siller… - Materials, 2019 - mdpi.com
In this work we present a novel algorithm for generating in-silico biomimetic models of a
cortical bone microstructure towards manufacturing biomimetic bone via additive …

Advanced modeling methods—applications to bone fracture mechanics

A Ural - Current Osteoporosis Reports, 2020 - Springer
Abstract Purpose of Review The goal of this review is to summarize recent advances in
modeling of bone fracture using fracture mechanics–based approaches at multiple length …

[HTML][HTML] Joining soft tissues to bone: Insights from modeling and simulations

A Tits, D Ruffoni - Bone Reports, 2021 - Elsevier
Entheses are complex multi-tissue regions of the musculoskeletal system serving the
challenging task of connecting highly dissimilar materials such as the compliant tendon to …

[HTML][HTML] Investigating the post-yield behavior of mineralized bone fibril arrays using a 3D non-linear finite element unit-cell model

E Alizadeh, S Omairey, P Zysset - journal of the mechanical behavior of …, 2023 - Elsevier
In this study, we propose a 3D non-linear finite element (FE) unit-cell model to investigate
the post-yield behavior of mineralized collagen fibril arrays (FAY). We then compare the …

Computational investigation of ultrastructural behavior of bone using a cohesive finite element approach

M Maghsoudi-Ganjeh, L Lin, X Wang… - … and modeling in …, 2019 - Springer
Bone ultrastructure at sub-lamellar length scale is a key structural unit in bone that bridges
nano-and microscale hierarchies of the tissue. Despite its influence on bulk response of …

Aging exacerbates the morphological and mechanical response of mineralized collagen fibrils in murine cortical bone to disuse

F Liu, K Hu, LH Al-Qudsy, LQ Wu, Z Wang, HY Xu… - Acta Biomaterialia, 2022 - Elsevier
Mineralized collagen fibrils (MCFs) are the fundamental building blocks of bone tissue and
contribute significantly to the mechanical behavior of bone. However, it is still largely …

A stochastic micro to macro mechanical model for the evolution of bone-implant interface stiffness

J Xie, D Rittel, K Shemtov-Yona, FA Shah, A Palmquist - Acta Biomaterialia, 2021 - Elsevier
Upon placement of an implant into living bone, an interface is formed through which various
biochemical, biological, physical, and mechanical interactions take place. This interface …

Effect of modifications in mineralized collagen fibril and extra-fibrillar matrix material properties on submicroscale mechanical behavior of cortical bone

Y Wang, A Ural - Journal of the Mechanical Behavior of Biomedical …, 2018 - Elsevier
A key length scale of interest in assessing the fracture resistance of bone is the
submicroscale which is composed of mineralized collagen fibrils (MCF) and extra-fibrillar …