Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup

LS Chawla, R Bellomo, A Bihorac… - Nature Reviews …, 2017 - nature.com
Consensus definitions have been reached for both acute kidney injury (AKI) and chronic
kidney disease (CKD) and these definitions are now routinely used in research and clinical …

Long-term outcomes of acute kidney injury and strategies for improved care

MT James, M Bhatt, N Pannu, M Tonelli - Nature Reviews Nephrology, 2020 - nature.com
Acute kidney injury (AKI), once viewed predominantly as a self-limited and reversible
condition, is now recognized as a growing problem associated with significant risks of …

[HTML][HTML] ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury

Y Wang, M Zhang, R Bi, Y Su, F Quan, Y Lin, C Yue… - Redox biology, 2022 - Elsevier
The term ferroptosis coined in 2012 causes acute kidney injury (AKI). However, its pathway
mechanism in AKI is poorly understood. In this study, we conducted an RNA-sequence …

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

C Chen, D Wang, Y Yu, T Zhao, N Min, Y Wu… - Cell death & …, 2021 - nature.com
Legumain is required for maintenance of normal kidney homeostasis. However, its role in
acute kidney injury (AKI) is still unclear. Here, we induced AKI by bilateral ischemia …

Ferroptosis, but not necroptosis, is important in nephrotoxic folic acid–induced AKI

D Martin-Sanchez, O Ruiz-Andres… - Journal of the …, 2017 - journals.lww.com
AKI is histologically characterized by necrotic cell death and inflammation. Diverse pathways
of regulated necrosis have been reported to contribute to AKI, but the molecular regulators …

The role of acute kidney injury in chronic kidney disease

RK Hsu, CY Hsu - Seminars in nephrology, 2016 - Elsevier
There is increasing recognition that acute kidney injury (AKI) and chronic kidney disease
(CKD) are closely linked and likely promote one another. Underlying CKD now is …

Pretreatment with Roxadustat (FG‐4592) Attenuates Folic Acid‐Induced Kidney Injury through Antiferroptosis via Akt/GSK‐3β/Nrf2 Pathway

X Li, Y Zou, J Xing, YY Fu, KY Wang… - Oxidative Medicine …, 2020 - Wiley Online Library
Folic acid‐(FA‐) induced kidney injury is characterized by the tubule damage due to the
disturbance of the antioxidant system and subsequent interstitial fibrosis. FG‐4592 is an …

Management of patients at risk of acute kidney injury

J Vanmassenhove, J Kielstein, A Jörres, W Van Biesen - The lancet, 2017 - thelancet.com
Acute kidney injury (AKI) is a multifaceted syndrome that occurs in different settings. The
course of AKI can be variable, from single hit and complete recovery, to multiple hits …

[HTML][HTML] Intermediate and long-term outcomes of survivors of acute kidney injury episodes: a large population-based cohort study

S Sawhney, A Marks, N Fluck, A Levin… - American Journal of …, 2017 - Elsevier
Background The long-term prognosis after acute kidney injury (AKI) is variable. It is unclear
how the prognosis of AKI and its relationship to prognostic factors (baseline kidney function …

Designing acute kidney injury clinical trials

A Zarbock, LG Forni, M Ostermann, C Ronco… - Nature Reviews …, 2024 - nature.com
Acute kidney injury (AKI) is a common clinical condition with various causes and is
associated with increased mortality. Despite advances in supportive care, AKI increases not …