Simulating tissue mechanics with agent-based models: concepts, perspectives and some novel results

P Van Liedekerke, MM Palm, N Jagiella… - Computational particle …, 2015 - Springer
In this paper we present an overview of agent-based models that are used to simulate
mechanical and physiological phenomena in cells and tissues, and we discuss underlying …

A quantitative high-resolution computational mechanics cell model for growing and regenerating tissues

P Van Liedekerke, J Neitsch, T Johann… - … and modeling in …, 2020 - Springer
Mathematical models are increasingly designed to guide experiments in biology,
biotechnology, as well as to assist in medical decision making. They are in particular …

Everything you always wanted to know about SDPD (but were afraid to ask)

M Ellero, P Español - Applied Mathematics and Mechanics, 2018 - Springer
An overview of the smoothed dissipative particle dynamics (SDPD) method is presented in a
format that tries to quickly answer questions that often arise among users and newcomers. It …

The role of actin protrusion dynamics in cell migration through a degradable viscoelastic extracellular matrix: Insights from a computational model

T Heck, DA Vargas, B Smeets, H Ramon… - PLoS computational …, 2020 - journals.plos.org
Actin protrusion dynamics plays an important role in the regulation of three-dimensional (3D)
cell migration. Cells form protrusions that adhere to the surrounding extracellular matrix …

Analysis of initial cell spreading using mechanistic contact formulations for a deformable cell model

T Odenthal, B Smeets, P Van Liedekerke… - PLoS computational …, 2013 - journals.plos.org
Adhesion governs to a large extent the mechanical interaction between a cell and its
microenvironment. As initial cell spreading is purely adhesion driven, understanding this …

Quantitative cell-based model predicts mechanical stress response of growing tumor spheroids over various growth conditions and cell lines

P Van Liedekerke, J Neitsch, T Johann… - PLoS computational …, 2019 - journals.plos.org
Model simulations indicate that the response of growing cell populations on mechanical
stress follows the same functional relationship and is predictable over different cell lines and …

Stability of asymmetric cell division: A deformable cell model of cytokinesis applied to C. elegans

M Cuvelier, J Vangheel, W Thiels, H Ramon, R Jelier… - Biophysical …, 2023 - cell.com
Cell division during early embryogenesis is linked to key morphogenic events such as
embryo symmetry breaking and tissue patterning. It is thought that the physical surrounding …

A numerically robust, parallel-friendly variant of BiCGSTAB for the semi-implicit integration of the viscous term in Smoothed Particle Hydrodynamics

G Bilotta, V Zago, V Centorrino, RA Dalrymple… - Journal of …, 2022 - Elsevier
Implicit integration of the viscous term can significantly improve performance in
computational fluid dynamics for highly viscous fluids such as lava. We show improvements …

Simulation of plant cell shrinkage during drying–A SPH–DEM approach

HCP Karunasena, W Senadeera, RJ Brown… - … Analysis with Boundary …, 2014 - Elsevier
Plant based dried food products are popular commodities in global market where much
research is focused to improve the products and processing techniques. In this regard …

Modeling extracellular matrix viscoelasticity using smoothed particle hydrodynamics with improved boundary treatment

T Heck, B Smeets, S Vanmaercke… - Computer Methods in …, 2017 - Elsevier
We propose viscoelastic smoothed particle hydrodynamics (SPH) with extended boundary
conditions as a new method to model the extracellular matrix (ECM) in contact with a …