Background Exposure to cigarette smoke (CS) is a major threat to human health worldwide.
It is well established that smoking increases the risk of respiratory diseases, cardiovascular …

Immune-mediated diseases are clinically heterogeneous but they share genetic and
pathogenic mechanisms. These diseases may develop from the interplay of genetic factors …

Objectives Non-selective histone deacetylase (HDAC) inhibitors (HDACi) have
demonstrated anti-inflammatory properties in both in vitro and in vivo models of rheumatoid …

Aging is a natural process characterized by the declining ability of the different organs and
tissues to respond to stress, increasing homeostatic imbalance and risk of disease …

The acetylation of histone and non-histone proteins has been implicated in several disease
states. Modulation of such epigenetic modifications has therefore made histone …

Histone deacetylases (HDACs) are a group of enzymes that control histone deacetylation
and bear potential to direct expression of large gene sets. We determined the effect of HDAC …

Diabetes mellitus (DM) is one of the principal manifestations of metabolic syndrome and its
prevalence with modern lifestyle is increasing incessantly. Chronic hyperglycemia can …

Introduction Polycythemia vera (PV), a Philadelphia chromosome-negative
myeloproliferative neoplasm, is characterized by panmyelosis, pancytosis, and a JAK2 …

Epigenetic modifiers of the histone deacetylase (HDAC) family contribute to autoimmunity,
cancer, HIV infection, inflammation, and neurodegeneration. Hence, histone deacetylase …

Epigenetics is defined as the stable and heritable alternations in gene expression without
changing the DNA nucleotide sequence. The initiation and progression of cancer result from …