The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

Psychedelics, also known as classical hallucinogens, have been investigated for decades
due to their potential therapeutic effects in the treatment of neuropsychiatric and substance …

The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …

Nutrient sensing is a mechanism for organisms to sense their environment. In larger
animals, including humans, the intestinal tract is a major site of nutrient sensing for the body …

Dysregulation of the corticotropin-releasing factor (CRF)–urocortin (UCN) system has been
implicated in stress-related psychopathologies such as depression and anxiety. It has been …

The~ 100 MB genome of C. elegans codes for~ 20,000 protein-coding genes many of which
are required for the function of the nervous system, composed of 302 neurons in the adult …

G protein-coupled receptors (GPCRs) play a central role in signal transmission, thereby
controlling many facets of cellular function. Overwhelming evidence now implicates GPCRs …

Advances in structural biology have provided important mechanistic insights into signaling
by the transmembrane core of G-protein coupled receptors (GPCRs); however, much less is …

Primary cilia are specialized microtubule‐based signaling organelles that convey
extracellular signals into a cellular response in most vertebrate cell types. The physiological …

Human luteinizing hormone (hLH) and chorionic gonadotropin (hCG) act on the same
receptor (LHCGR) but it is not known whether they elicit the same cellular and molecular …