Ultrasound-assisted green synthesis of triazole-based azomethine/thiazolidin-4-one hybrid inhibitors for cancer therapy through targeting dysregulation signatures of …
AH Abdelmonsef, AM El-Saghier… - Green Chemistry Letters …, 2023 - Taylor & Francis
The overexpression of Rab proteins was linked to cancer development, making this family of
proteins an attractive drug target for the identification of novel inhibitors against tumor …
proteins an attractive drug target for the identification of novel inhibitors against tumor …
Novel 2-acetamido-2-ylidene-4-imidazole derivatives (El-Saghier reaction): Green synthesis, biological assessment, and molecular docking
AM El-Saghier, A Abdou, MAA Mohamed… - ACS …, 2023 - ACS Publications
El-Saghier reaction is the novel, general, and green reaction of various amines with ethyl
cyanoacetate and ethyl glycinate hydrochloride. A new series of imidazolidin-4-ones and bis …
cyanoacetate and ethyl glycinate hydrochloride. A new series of imidazolidin-4-ones and bis …
Synthetic and biological attributes of pyrimidine derivatives: A recent update
Nitrogen-containing heterocycles attract the attention of chemists due to their multifarious
activities. Amongst all, pyrimidine plays a central role and exhibits a broad spectrum of …
activities. Amongst all, pyrimidine plays a central role and exhibits a broad spectrum of …
An operationally simple, one‐pot, convenient synthesis, and in vitro anti‐inflammatory activity of some new spirotriazolotriazine derivatives
AM El‐Saghier, SS Enaili, A Abdou… - Journal of …, 2024 - Wiley Online Library
The wide biological actions of triazolotriazine hybrids, benzene‐sulfonamide derivatives,
exhibit a good chance of displaying in vitro anti‐inflammatory effects. An operationally …
exhibit a good chance of displaying in vitro anti‐inflammatory effects. An operationally …
An efficient eco-friendly, simple, and green synthesis of some new spiro-N-(4-sulfamoyl-phenyl)-1, 3, 4-thiadiazole-2-carboxamide derivatives as potential inhibitors of …
Introduction The coronavirus disease 2019 (COVID-19) pandemic has caused a global
health crisis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a …
health crisis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a …
1, 2, 4‐Triazole and benzimidazole fused dihydropyrimidine derivatives: Design, green synthesis, antibacterial, antitubercular, and antimalarial activities
This study reports the design and synthesis of novel 1, 2, 4‐triazolo/benzimidazolo‐
pyrimidine linked 1‐benzyl‐4‐[(p‐tolyloxy) methyl]‐1, 2, 3‐triazole derivatives as potent …
pyrimidine linked 1‐benzyl‐4‐[(p‐tolyloxy) methyl]‐1, 2, 3‐triazole derivatives as potent …
The Synthesis, Antimicrobial Activity, and Molecular Docking of New 1, 2, 4-Triazole, 1, 2, 4-Triazepine, Quinoline, and Pyrimidine Scaffolds Condensed to Naturally …
AA Abu-Hashem, SA Al-Hussain - Pharmaceuticals, 2022 - mdpi.com
This study aims to synthesize a new series of furochromone derivatives, evaluate their
antimicrobial properties, and improve the permeability of potent compounds to inhibit …
antimicrobial properties, and improve the permeability of potent compounds to inhibit …
Modulating leishmanial pteridine metabolism machinery via some new coumarin-1, 2, 3-triazoles: design, synthesis and computational studies
NW Hassan, A Sabt, MAZ El-Attar, M Ora… - European Journal of …, 2023 - Elsevier
In accordance with WHO statistics, leishmaniasis is one of the top neglected tropical
diseases, affecting around 700 000 to one million people per year. To that end, a new series …
diseases, affecting around 700 000 to one million people per year. To that end, a new series …
Biological activity of triazolopyrimidine copper (II) complexes modulated by an auxiliary NN-chelating heterocycle ligands
Novel complexes of type [Cu (NN)(dmtp) 2 (OH2)](ClO4) 2· dmtp ((1) NN: 2, 2′-
bipyridine;(2) L: 1, 10-phenantroline and dmtp: 5, 7-dimethyl-1, 2, 4-triazolo [1, 5-a] …
bipyridine;(2) L: 1, 10-phenantroline and dmtp: 5, 7-dimethyl-1, 2, 4-triazolo [1, 5-a] …
Synthesis of some new thiadiazole/thiadiazine derivatives as potent biologically active compounds
AM El-Saghier, A Abdul-Baset… - Sohag Journal of …, 2023 - sjsci.journals.ekb.eg
Due to the significant pharmacological and industrial value of 1, 3, 4-thiadiazole and 1, 3, 4-
thiadiazine, they are continuing to be of considerable interest to many researchers, therefore …
thiadiazine, they are continuing to be of considerable interest to many researchers, therefore …