BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

Development of the early embryo takes place under low oxygen tension. Under such
conditions, the embryo implants and the trophectoderm, the outer layer of blastocyst …

In human pregnancy, successful placentation and remodelling of the uterine vasculature
require the integration of a number of stages, which are crucial for a healthy pregnancy. As …

In humans, cell fusion is restricted to only a few cell types under normal conditions. In the
placenta, cell fusion is a critical process for generating syncytiotrophoblast: the giant …

The success of pregnancy is a result of countless ongoing interactions between the placenta
and the maternal immune and cardiovascular systems. Pre‐eclampsia is a serious …

The combination of EGF, CHIR99021, A83-01, SB431542, VPA, and Y27632 (EGF/CASVY)
facilitates the derivation of trophoblast stem (TS) cells from human blastocysts and first …

FBXW2 inhibits proliferation of lung cancer cells by targeting SKP2 for degradation. Whether
and how FBXW2 regulates tumor invasion and metastasis is previously unknown. Here, we …

Placental dysfunction refers to the insufficiency of placental perfusion and chronic hypoxia
during early pregnancy, which impairs placental function and causes inadequate supply of …

The human placenta is a poorly-understood organ, but one that is critical for proper
development and growth of the fetus in-utero. The epithelial cell type that contributes to …

Approximately 8% of the human genome, over four times more than its protein-coding
regions, comprises sequences of viral origin that are known as human endogenous …