Human exposure to antidepressants in the United States has rapidly escalated in recent
years. Although millions of Americans therapeutically take this class of neuroactive drugs on …

Objective: To review the evidence that plasma alkalinization improves the outcome in
tricyclic antidepressant toxicity. Methods: Medline search from 1966 to October 2000 …

Cocaine is a local anesthetic with the potential to induce dysrhythmia due to direct
myocardial sodium channel antagonism similar to class I antidysrhythmic drugs. The …

Magnolia bark combined with ginger rhizome is a common drug pair in traditional Chinese
prescriptions for the treatment of depression. In the present study, we examined …

The tricyclic antidepressant agents hold an important place in the history of treatments for
depression. They were the first class of antidepressant compounds to be widely used in …

Abstract Purpose of Review The purpose of this review is to provide an overview of
psychiatric medications that impact blood pressure in adult patients either as a direct side …

Tricyclic antidepressants (TCA), increasingly prescribed for multiple indications in children
and adults, are responsible for many pediatric poisonings. Though the majority of TCA …

Patients taking amitriptyline (AMT) have an increased risk of sudden cardiac death, yet the
mechanism for AMT's proarrhythmic effects remains incompletely understood. Here, we …

Generalized seizure activity may be a presenting symptom of poisoning or a preterminal
manifestation of serious toxicity. Seizures may result from a large number of drugs and …

Objectives: To measure the effect of tricyclic antidepressant drugs (TCAs) on human
myocardial contractility. Methods: Human atrial tissue was obtained during cardiac bypass …