Digitally enabled, patient‐centric clinical trials: shifting the drug development paradigm

MF Dockendorf, BJ Hansen… - Clinical and …, 2021 - Wiley Online Library
The rapidly advancing field of digital health technologies provides a great opportunity to
radically transform the way clinical trials are conducted and to shift the clinical trial paradigm …

Effect of Crocus sativus (Saffron) Intake on Top of Standard Treatment, on Disease Outcomes and Comorbidities in Patients with Rheumatic Diseases: Synthesis …

SG Tsiogkas, MG Grammatikopoulou, K Gkiouras… - Nutrients, 2021 - mdpi.com
Rheumatic diseases (RDs) are often complicated by chronic symptoms and frequent side-
effects associated with their treatment. Saffron, a spice derived from the Crocus sativus L …

Comparison of different methods to assess tacrolimus concentration intra-patient variability as potential marker of medication non-adherence

B Kostalova, K Mala-Ladova, SD Sulkova… - Frontiers in …, 2022 - frontiersin.org
Background and objective: Non-adherence to tacrolimus commonly manifests as low drug
concentrations and/or high intra-patient variability (IPV) of concentrations across multiple …

Evaluation, analysis, and reporting of medication adherence for clinical trials of anticoagulants in children: guidance from the ISTH SSC Subcommittee on Pediatric …

ME McGrady, V Ignjatovic, S Jones, A Bruce… - Journal of Thrombosis …, 2024 - Elsevier
In response to growing recognition that nonadherence prevents children, adolescents, and
young adults from achieving the therapeutic benefits of anticoagulant medication, the …

Effect and usability of mobile health applications for medication adherence in patients with heart failure: a systematic review

KAAL de Barros, MF da Silva Praxedes… - International Journal of …, 2023 - Elsevier
Background This review aimed to evaluate the effect of mobile health applications (apps)
use on medication adherence in heart failure (HF) patients, and to verify their quality of use …

Measuring and reporting treatment adherence: What can we learn by comparing two respiratory conditions?

H Tibble, M Flook, A Sheikh, A Tsanas… - British journal of …, 2021 - Wiley Online Library
Medication non‐adherence, defined as any deviation from the regimen recommended by
their healthcare provider, can increase morbidity, mortality and side effects, while reducing …

Drug development for major chronic health conditions—aligning with growing public health needs: Proceedings from a multistakeholder think tank

KA Krychtiuk, TLG Andersson, U Bodesheim… - American Heart …, 2024 - Elsevier
The global pharmaceutical industry portfolio is skewed towards cancer and rare diseases
due to more predictable development pathways and financial incentives. In contrast, drug …

Real-world evidence for adherence and persistence with atorvastatin therapy

K Tsioufis, JM Castellano Vázquez, G Sykara… - Cardiology and …, 2021 - Springer
Atorvastatin, which has been approved by regulatory agencies for primary-and secondary-
prevention patients with dyslipidemia, has historically been the most commonly prescribed …

Patient and healthcare provider perspectives on adherence with antihypertensive medications: an exploratory qualitative study in Tanzania

A Edward, B Campbell, F Manase, LJ Appel - BMC health services …, 2021 - Springer
Background Poor medication adherence is an extraordinarily common problem worldwide
that contributes to inadequate control of many chronic diseases, including Hypertension …

Medication Adherence Measurement Methods in Registration Trials Supporting the Approval of New Medicines: A Cross‐Sectional Analysis of Centralized …

KM Mantila, AMG Pasmooij… - Clinical …, 2022 - Wiley Online Library
Medication adherence is a key factor impacting efficacy and safety of medicines, yet how it is
dealt with in European registration trials is unknown. A cross‐sectional analysis of European …