The brain is highly enriched with fatty acids. These include the polyunsaturated fatty acids
(PUFAs) arachidonic acid and docosahexaenoic acid, which are largely esterified to the …

Lipids are vital components of many biological processes and crucial in the pathogenesis of
numerous common diseases, but the specific mechanisms coupling intracellular lipids to …

Fatty acid-binding proteins (FABPs) are members of the intracellular lipid-binding protein
(iLBP) family and are involved in reversibly binding intracellular hydrophobic ligands and …

Reactive astrocytes undergo morphological, molecular, metabolic, and functional
remodeling in response to central nervous system (CNS) damage. However, we still know …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential fatty acids that are provided
by dietary intake. Growing evidence suggests that n-3 and n-6 PUFAs are paramount for …

Essential polyunsaturated fatty acids (PUFAs) have profound effects on brain development
and function. Abnormalities of PUFA status have been implicated in neuropsychiatric …

Until recently, glial cells have been considered mainly support cells for neurons in the
mammalian brain. However, many studies have unveiled a variety of glial functions …

The intracellular fatty acid-binding proteins (FABPs) are abundantly expressed in almost all
tissues. They exhibit high affinity binding of a single long-chain fatty acid, with the exception …

Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable
proportion of the human population and severely compromise quality of life. Therefore …