Activation of human endogenous retroviruses and its physiological consequences
Human endogenous retroviruses (HERVs) are abundant sequences that persist within the
human genome as remnants of ancient retroviral infections. These sequences became fixed …
human genome as remnants of ancient retroviral infections. These sequences became fixed …
[HTML][HTML] The integral role of magnesium in muscle integrity and aging: a comprehensive review
ACR Souza, AR Vasconcelos, DD Dias, G Komoni - Nutrients, 2023 - mdpi.com
Aging is characterized by significant physiological changes, with the degree of decline
varying significantly among individuals. The preservation of intrinsic capacity over the …
varying significantly among individuals. The preservation of intrinsic capacity over the …
Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis
KC Stein, F Morales-Polanco, J van der Lienden… - Nature, 2022 - nature.com
Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-
related protein misfolding diseases,. Yet, how ageing impairs proteostasis remains unclear …
related protein misfolding diseases,. Yet, how ageing impairs proteostasis remains unclear …
Distinct longevity mechanisms across and within species and their association with aging
Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …
Clonal hematopoiesis–driver DNMT3A mutations alter immune cells in heart failure
WT Abplanalp, S Cremer, D John, J Hoffmann… - Circulation …, 2021 - Am Heart Assoc
Rationale: Clonal hematopoiesis driven by mutations of DNMT3A (DNA methyltransferase
3a) is associated with increased incidence of cardiovascular disease and poor prognosis of …
3a) is associated with increased incidence of cardiovascular disease and poor prognosis of …
Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney
Little is known about the molecular changes that take place in the kidney during the aging
process. In order to better understand these changes, we measured mRNA and protein …
process. In order to better understand these changes, we measured mRNA and protein …
Large‐scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals
Lifespan varies significantly among mammals, with more than 100‐fold difference between
the shortest and longest living species. This natural difference may uncover the evolutionary …
the shortest and longest living species. This natural difference may uncover the evolutionary …
Upregulation of ribosome complexes at the blood-brain barrier in Alzheimer's disease patients
M Suzuki, K Tezuka, T Handa, R Sato… - Journal of Cerebral …, 2022 - journals.sagepub.com
The cerebrovascular-specific molecular mechanism in Alzheimer's disease (AD) was
investigated by employing comprehensive and accurate quantitative proteomics. Highly …
investigated by employing comprehensive and accurate quantitative proteomics. Highly …
Effect of stimulation time on the expression of human macrophage polarization markers
D Unuvar Purcu, A Korkmaz, S Gunalp, DG Helvaci… - PloS one, 2022 - journals.plos.org
Macrophages are highly plastic cells that can polarize into functionally distinct subsets in
vivo and in vitro in response to environmental signals. The development of protocols to …
vivo and in vitro in response to environmental signals. The development of protocols to …
Cell death or survival: Insights into the role of mRNA translational control
Cellular stress is an intrinsic part of cell physiology that underlines cell survival or death. The
ability of mammalian cells to regulate global protein synthesis (aka translational control) …
ability of mammalian cells to regulate global protein synthesis (aka translational control) …