N-methyl-d-aspartate (NMDA) receptor antagonists have therapeutic potential in numerous
CNS disorders ranging from acute neurodegeneration (eg stroke and trauma), chronic …

Hyperammonemia resulting from inherited urea cycle enzyme deficiencies or liver failure
results in severe central nervous system dysfunction including brain edema, convulsions …

Glutamate is the principal excitatory neurotransmitter in the brain. Knowledge of the
glutamatergic synapse has advanced enormously over the last 10 years, primarily through …

Removal of extracellular glutamate at synapses, by specific high-affinity glutamate
transporters, is critical to prevent excitotoxic injury to neurons. Oxidative stress has been …

Hepatic encephalopathy (HE) and portal–systemic encephalopathy (PSE) are the terms
used interchangeably to describe a complex neuropsychiatric syndrome associated with …

This study utilized a unilateral controlled cortical impact model of traumatic brain injury to
assess disruptions of synaptic homeostasis following trauma. Adult rats were subjected to a …

While the pathogenesis of hepatic encephalopathy (HE) remains elusive, there is
considerable evidence pointing to a key role of ammonia-induced dysfunction of astrocytes …

Neuropsychiatric symptoms of hyperammonaemia include alterations of mood and
personality, cognitive impairment, ataxia, convulsions and coma. The nature and severity of …

Synapse loss, deposits of amyloid β‐peptide (Aβ), impaired energy metabolism, and
cognitive deficits are defining features of Alzheimer's disease (AD). Estrogen replacement …

It has been proposed that alterations of excitatory and inhibitory amino acids play a role in
the pathogenesis of hepatic encephalopathy in acute liver failure. To evaluate this …