Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into
the dynamic circuit architecture of brain disorders. This Review illustrates our current …

Translational experimental approaches that help us better trace Parkinson's disease (PD)
pathophysiological mechanisms leading to new therapeutic targets are urgently needed. In …

Background Despite the large body of work on local field potentials (LFPs), a measure of
oscillatory activity in patients with Parkinson's disease (PD), the longitudinal evolution of …

Objective Bradykinesia and rigidity are considered closely related motor signs in Parkinson
disease (PD), but recent neurophysiological findings suggest distinct pathophysiological …

The role of brain asymmetries of dopaminergic neurons in motor symptoms of Parkinson's
disease is still undefined. Local field recordings from the subthalamic nucleus revealed …

Deep brain stimulation is a brain circuit intervention that can modulate distinct neural
pathways for the alleviation of neurological symptoms in patients with brain disorders. In …

Clinically available deep brain recordings in patients with Parkinson disease (PD) offer
insights into disease mechanisms and create a pathway for personalized treatment …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of
dopaminergic cells in the substantia nigra pars compacta and other brainstem nuclei. 1 …

Adaptive deep brain stimulation (DBS) provides individualized therapy for people with
Parkinson's disease (PWP) by adjusting the stimulation in real-time using neural signals that …

Neurological disorders are the leading cause of disability-adjusted life years and the second
leading cause of death worldwide, with most having no cure. Ensuring people with …