Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function as well as likely abnormalities in glial cells. While …

Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

In the present article the putative role of environmental factors in schizophrenia is reviewed
and synthesized. Accumulating evidence from recent studies suggests that environmental …

While multiple theories have been put forth regarding the origin of schizophrenia, by far the
vast majority of evidence points to the neurodevelopmental model in which developmental …

DNA methylation is a covalent chemical modification of DNA catalyzed by DNA
methyltransferases (DNMTs). DNA methylation is associated with transcriptional silencing …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

Epigenetic mechanisms, which include DNA methylation, a variety of post-translational
modifications of histone proteins (acetylation, phosphorylation, methylation, ubiquitination …

Fortification of food with folic acid to reduce the number of neural tube defects was
introduced 10 y ago in North America. Many countries are considering whether to adopt this …

There are numerous examples in psychology and other disciplines of the enduring effects of
early experience on neural function. In this article, we review the emerging evidence for …

Traditionally, γ-aminobutyric acid (GABA) is best known for its role as a primary inhibitory
neurotransmitter reducing neuronal excitability in the mammalian central nervous system …