Investigation of contacts of patients with tuberculosis (TB) is a priority for TB control in high-
income countries, and is increasingly being considered in resource-limited settings. This …

Tuberculosis continues to cause an unacceptably high toll of disease and death among
children worldwide, particularly in the wake of the HIV epidemic. Increased international …

Abstract Background. Individuals infected with Mycobacterium tuberculosis (Mtb) may
develop symptoms and signs of disease (tuberculosis disease) or may have no clinical …

In 2005, CDC published guidelines for using the QuantiFERON-TB Gold test (QFT-
G)(Cellestis Limited, Carnegie, Victoria, Australia)(CDC. Guidelines for using the …

Background: Until recently, the tuberculin skin test was the only test for detecting latent
tuberculosis (TB) infection, but 2 ex vivo interferon-γ release assays (IGRAs) are now …

The individual-and population-level impact of household tuberculosis exposure on
transmission is unclear but may have implications for the effectiveness and implementation …

Background. Diagnosis of childhood tuberculosis (TB) is challenging. The widely used
tuberculin skin test (TST) may produce-positive results because of cross-reactivity with …

The last decade has witnessed significant advances in mycobacterial genomics and cellular
research which have resulted in the development of two new blood tests, the enzyme-linked …

Background: The utility of interferon gamma release assays (IGRAs) has been assessed in
adults, but remains unclear in children. We reviewed the literature on the use of a …

A profusion of articles have been published on the accuracy and uses of interferon‐gamma
releasing assays. Here we review the clinical applications, advantages, and limitations of …