Steering and controlling evolution—from bioengineering to fighting pathogens
M Lässig, V Mustonen, A Nourmohammad - Nature Reviews Genetics, 2023 - nature.com
Control interventions steer the evolution of molecules, viruses, microorganisms or other cells
towards a desired outcome. Applications range from engineering biomolecules and …
towards a desired outcome. Applications range from engineering biomolecules and …
Protein ensembles link genotype to phenotype
R Nussinov, CJ Tsai, H Jang - PLoS computational biology, 2019 - journals.plos.org
Classically, phenotype is what is observed, and genotype is the genetic makeup. Statistical
studies aim to project phenotypic likelihoods of genotypic patterns. The traditional genotype …
studies aim to project phenotypic likelihoods of genotypic patterns. The traditional genotype …
Population immunity predicts evolutionary trajectories of SARS-CoV-2
The large-scale evolution of the SARS-CoV-2 virus has been marked by rapid turnover of
genetic clades. New variants show intrinsic changes, notably increased transmissibility, and …
genetic clades. New variants show intrinsic changes, notably increased transmissibility, and …
The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA. 1 evolution
The Omicron BA. 1 variant of SARS-CoV-2 escapes convalescent sera and monoclonal
antibodies that are effective against earlier strains of the virus. This immune evasion is …
antibodies that are effective against earlier strains of the virus. This immune evasion is …
Receptor binding, immune escape, and protein stability direct the natural selection of SARS-CoV-2 variants
V Upadhyay, A Lucas, S Panja, R Miyauchi… - Journal of Biological …, 2021 - ASBMB
Emergence of new severe acute respiratory syndrome coronavirus 2 variants has raised
concerns related to the effectiveness of vaccines and antibody therapeutics developed …
concerns related to the effectiveness of vaccines and antibody therapeutics developed …
Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies
Over the past two decades, several broadly neutralizing antibodies (bnAbs) that confer
protection against diverse influenza strains have been isolated. Structural and biochemical …
protection against diverse influenza strains have been isolated. Structural and biochemical …
[HTML][HTML] From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics
Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …
Single-cell herpes simplex virus type 1 infection of neurons using drop-based microfluidics reveals heterogeneous replication kinetics
Single-cell analyses of viral infections reveal heterogeneity that is not detected by traditional
population-level studies. This study applies drop-based microfluidics to investigate the …
population-level studies. This study applies drop-based microfluidics to investigate the …
Influenza A viral burst size from thousands of infected single cells using droplet quantitative PCR (dqPCR)
An important aspect of how viruses spread and infect is the viral burst size, or the number of
new viruses produced by each infected cell. Surprisingly, this value remains poorly …
new viruses produced by each infected cell. Surprisingly, this value remains poorly …
Viral evolution shaped by host proteostasis networks
J Yoon, JE Patrick, CB Ogbunugafor… - Annual Review of …, 2023 - annualreviews.org
Understanding the factors that shape viral evolution is critical for developing effective
antiviral strategies, accurately predicting viral evolution, and preventing pandemics. One …
antiviral strategies, accurately predicting viral evolution, and preventing pandemics. One …