One of the cardinal features of inflammatory states is that normally innocuous stimuli
produce pain. Since the publication of the Melzack±Wall gate control theory in 1965, 45 it …

Migraine is a common episodic headache disorder. A comprehensive headache treatment
plan includes acute attack treatment to relieve pain and impairment and long-term …

Stargazer mice have spike-wave seizures characteristic of absence epilepsy, with
accompanying defects in the cerebellum and inner ear. We describe here a novel gene …

The authors of the first edition worked together again to revise data for the second edition of
this popular volume. Based at three of the world's leading centers for the study and treatment …

Migraine is a common episodic headache disorder with a 1-year prevalence of
approximately 18% in women, 6% in men, and 4% in children. It is characterized by attacks …

High voltage-activated Ca2+ channels of the CaV1. 2 class (L-type) are crucial for excitation-
contraction coupling in both cardiac and smooth muscle. These channels are regulated by a …

Purpose: To review recent findings concerning Ca2+ channel subtype/structure/function
from electrophysiological and molecular biological studies and to explain Ca2+ channel …

Mammalian sperm contain a single large secretory vesicle, or acrosome. Exocytosis of this
vesicle (the acrosome reaction) occurs as an early step in the gamete interaction process …

Based on the body of evidence implicating ocular blood flow disturbances in the
pathogenesis of glaucoma, there is great interest in the investigation of the effects of …

The diameters of small arteries and arterioles are tightly regulated by the dynamic
interaction between Ca2+ and K+ channels in the vascular smooth muscle cells. Calcium …