Streptococci readily colonize mucosal tissues in the nasopharynx; the respiratory,
gastrointestinal, and genitourinary tracts; and the skin. Each ecological niche presents a …

Iron is a versatile redox-active catalyst and a required cofactor within a diverse array of
biological processes. To almost all organisms, iron is both essential and potentially toxic …

The zebrafish holds much promise as a high-throughput drug screening model for immune-
related diseases, including inflammatory and infectious diseases and cancer. This is due to …

The zebrafish has emerged as a powerful new vertebrate model of human disease. Initially
prominent in developmental biology, the zebrafish has now been adopted into varied fields …

The zebrafish, Danio rerio, has come to the forefront of biomedical research as a powerful
model for the study of development, neurobiology, and genetics of humans. In recent years …

The amenability of the zebrafish to in vivo imaging and genetic analysis has fueled
expanded use of this vertebrate model to investigate the molecular and cellular foundations …

Neutrophils are highly motile phagocytic cells that play a critical role in the immune
response to infection. Zebrafish (Danio rerio) are increasingly used to study neutrophil …

In recent years we have studied the relationship between strain genotypes and patient
phenotypes in group A Streptococcus (GAS), a model human bacterial pathogen that causes …

Streptococcus pyogenes is an obligate human pathobiont associated with many disease
states. Here, we present a model of S. pyogenes infection using intact murine epithelium …

ABSTRACT The 1,815,783-bp genome of a serotype M49 strain of Streptococcus pyogenes
(group A streptococcus [GAS]), strain NZ131, has been determined. This GAS strain (FCT …