Although mitochondrial contributions to cancer have been recognised for approximately a
century, given that mitochondrial DNA (mtDNA) is dwarfed by the size of the nuclear genome …

Mitochondria are highly dynamic organelles which can change their shape, via processes
termed fission and fusion, in order to adapt to different environmental and developmental …

Mitochondria, well recognized as the “powerhouse” of cells, are maternally inherited
organelles with bacterial ancestry that play essential roles in a myriad of cellular functions. It …

Environmental factors including diet, sedentary lifestyle and exposure to pollutants largely
influence human health throughout life. Cellular and molecular events triggered by an …

Apoptosis, the most extensively studied form of programmed cell death, is essential for
organismal homeostasis. Apoptotic cell death has widely been reported as a tumor …

Background: Kidney renal clear cell carcinoma (KIRC) is the malignancy originated from the
renal epithelium, with a high rate of distant metastasis. Aberrant alternative splicing (AS) of …

Many tumors are now understood to be heterogenous cell populations arising from a
minority of epithelial-like cancer stem cells (CSCs). CSCs demonstrate distinctive metabolic …

The crosstalk between tumor cells and the adjacent normal epithelium contributes to cancer
progression, but its regulators have remained elusive. Here, we show that breast cancer …

Abstract Mitochondrial Rho GTPases (MIRO1 and MIRO2) are primarily studied for their role
as resident mitochondrial anchor proteins that facilitate mitochondria trafficking in neurons …

Changes in metabolism that affect mitochondrial and glycolytic networks are hallmarks of
cancer, but their impact in disease is still elusive. Using global proteomics and ubiquitome …