Glioblastoma multiforme (GBM) is the most common adult primary brain tumor. The standard
clinical treatment of GBM includes a maximal surgical resection followed by concomitant …

Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical
outcome. The significance of hypoxia in the development of resistance to radiotherapy has …

In cancer patients, immune cells are often functionally compromised due to the
immunosuppressive features of the tumor microenvironment (TME) which contribute to the …

Hypoxia is a common feature of solid tumors that contributes to angiogenesis, invasiveness,
metastasis, altered metabolism and genomic instability. As hypoxia is a major actor in tumor …

Simple Summary Hypoxia is a key feature of the tumor microenvironment involved in the
pathogenesis of pancreatic ductal adenocarcinoma (PDAC). In this review we will highlight …

Low tissue oxygenation significantly impairs the effectiveness of cancer therapy and
promotes a more aggressive phenotype. Many strategies to improve tissue oxygenation …

The human body is a highly aerobic organism, which needs large amount of oxygen,
especially in tissues characterized by high metabolic demand, such as the heart. Inadequate …

The purpose of this manuscript is to provide an overview of methods that are termed EPR
oximetry and to describe how these techniques have been successfully applied to …

Purpose Tumor hypoxia is a major limiting factor for successful radiation therapy outcomes,
with hypoxic cells being up to 3-fold more radiation resistant than normoxic cells; tumor …

The hypoxic microenvironment is crucial for tumour cell growth and invasiveness. Tumour
tissue results from adaptation to reduced oxygen availability. Hypoxia first activates pro …